CDCA5
Sororin
Also known as: CDCA5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96FF9
- Gene
- CDCA5
- Ensembl
- ENSG00000146670
- Chromosome
- 11
- Canonical length
- 252 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable chromatin binding activity. Involved in chromosome organization; double-strand break repair; and positive regulation of exit from mitosis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
252 residues, UniProt reviewed canonical sequence.
>Q96FF9|CDCA5
1 MSGRRTRSGG AAQRSGPRAP SPTKPLRRSQ RKSGSELPSI LPEIWPKTPS AAAVRKPIVL
61 KRIVAHAVEV PAVQSPRRSP RISFFLEKEN EPPGRELTKE DLFKTHSVPA TPTSTPVPNP
121 EAESSSKEGE LDARDLEMSK KVRRSYSRLE TLGSASTSTP GRRSCFGFEG LLGAEDLSGV
181 SPVVCSKLTE VPRVCAKPWA PDMTLPGISP PPEKQKRKKK KMPEILKTEL DEWAAAMNAE
241 FEAAEQFDLL VELocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDCA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 50 nTPM
- testis: 37 nTPM
- thymus: 26 nTPM
- lymph node: 16 nTPM
- tonsil: 15 nTPM
- appendix: 9.9 nTPM
Single-cell type
- late spermatids: 208 nCPM
- late primary spermatocytes: 104 nCPM
- monocyte progenitors: 59 nCPM
- early spermatids: 49 nCPM
- differentiating spermatogonia: 48 nCPM
- erythrocyte progenitors: 48 nCPM
Immune cell
- NK-cell: 2.8 nTPM
- T-reg: 2 nTPM
- total PBMC: 0.7 nTPM
- memory CD4 T-cell: 0.5 nTPM
- naive B-cell: 0.5 nTPM
- gdT-cell: 0.4 nTPM
Brain region
- thalamus: 3.5 nTPM
- cerebral cortex: 3.4 nTPM
- pons: 3 nTPM
- white matter: 2.4 nTPM
- basal ganglia: 2.3 nTPM
- midbrain: 2.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.1
- DepMap mean gene effect
- -0.89
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Sororin protein
- Sororin-like, middle region
- Sororin, C-terminal region
- Sororin, middle region
- Sororin C-terminal region
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CDCA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDCA5 as an antibody target. Whether an autoantibody or antibody against CDCA5 could matter depends on whether native CDCA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDCA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDCA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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