Seroatlas · Human Serome Atlas

NAA16

N-alpha-acetyltransferase 16, NatA auxiliary subunit

Also known as: FLJ22054, MGC40612, NAA16_HUMAN, NARG1L, PRO2435

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6N069
Gene: NAA16
Ensembl: ENSG00000172766
Chromosome: 13
Canonical length: 864 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables ribosome binding activity. Involved in N-terminal protein amino acid acetylation; negative regulation of apoptotic process; and protein stabilization. Located in cytosol. Part of NatA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

864 residues, UniProt reviewed canonical sequence.

>Q6N069|NAA16
     1  MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG
    61  KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL
   121  SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV
   181  PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL
   241  KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL
   301  VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS
   361  PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH
   421  IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN
   481  EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD
   541  LLRLEDILRR HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR
   601  RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV ENPLEEAVKF
   661  LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA INSNNPWLHE CLIRFSKSVS
   721  NHSNLPDIVS KVLSQEMQKI FVKKDLESFN EDFLKRNATS LQHLLSGAKM MYFLDKSRQE
   781  KAIAIATRLD ETIKDKDVKT LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA
   841  VNEVDNPNVA LNHTANYDVL ANEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
pancreas: 19 nTPM
testis: 7 nTPM
lymph node: 6.1 nTPM
endometrium: 5.9 nTPM
retina: 5.5 nTPM

Single-cell type

myonuclei: 154 nCPM
pancreatic acinar cells: 142 nCPM
neutrophil progenitors: 112 nCPM
choroid plexus epithelial cells: 103 nCPM
pituitary stem cells: 97 nCPM
sertoli cells: 96 nCPM

Immune cell

naive CD8 T-cell: 4.8 nTPM
naive CD4 T-cell: 4.5 nTPM
basophil: 4.4 nTPM
NK-cell: 3.4 nTPM
eosinophil: 3.1 nTPM
memory CD4 T-cell: 2.6 nTPM

Brain region

cerebellum: 18 nTPM
cerebral cortex: 16 nTPM
white matter: 14 nTPM
hypothalamus: 13 nTPM
midbrain: 12 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA16 as an antibody target. Whether an autoantibody or antibody against NAA16 could matter depends on whether native NAA16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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