Seroatlas · Human Serome Atlas

HYPK

Huntingtin-interacting protein K

Also known as: C15orf63, FLJ20431, HSPC136, HYPK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX55
Gene: HYPK
Ensembl: ENSG00000242028
Chromosome: 15
Canonical length: 121 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules

OverviewNCBI Gene

Enables protein folding chaperone. Involved in negative regulation of apoptotic process and protein stabilization. Located in cytoplasm; microtubule cytoskeleton; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>Q9NX55|HYPK
     1  MATEGDVELE LETETSGPER PPEKPRKHDS GAADLERVTD YAEEKEIQSS NLETAMSVIG
    61  DRRSREQKAK QEREKELAKV TIKKEDLELI MTEMEISRAA AERSLREHMG NVVEALIALT
   121  N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HYPK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 25 nTPM
skeletal muscle: 23 nTPM
heart muscle: 16 nTPM
tongue: 14 nTPM
spinal cord: 14 nTPM
midbrain: 13 nTPM

Single-cell type

oligodendrocytes: 28 nCPM
other brain neurons: 26 nCPM
brain excitatory neurons: 25 nCPM
brain inhibitory neurons: 24 nCPM
astrocytes: 20 nCPM
oligodendrocyte progenitor cells: 19 nCPM

Immune cell

non-classical monocyte: 48 nTPM
plasmacytoid DC: 40 nTPM
intermediate monocyte: 38 nTPM
naive B-cell: 32 nTPM
memory B-cell: 30 nTPM
naive CD4 T-cell: 30 nTPM

Brain region

cerebellum: 18 nTPM
midbrain: 16 nTPM
white matter: 16 nTPM
cerebral cortex: 15 nTPM
hypothalamus: 15 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.04
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.87
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein folding chaperone

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nascent polypeptide-associated complex subunit alpha-like, UBA domain
HYPK UBA domain
Huntingtin-interacting protein K, UBA-like domain
Huntingtin-interacting protein K

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HYPK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HYPK as an antibody target. Whether an autoantibody or antibody against HYPK could matter depends on whether native HYPK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HYPK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HYPK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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