Seroatlas · Human Serome Atlas

NAA15

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Also known as: FLJ13340, NAA15_HUMAN, NARG1, NATH, TBDN100

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXJ9
Gene: NAA15
Ensembl: ENSG00000164134
Chromosome: 4
Canonical length: 866 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

866 residues, UniProt reviewed canonical sequence.

>Q9BXJ9|NAA15
     1  MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA MKGLTLNCLG
    61  KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKWD KDNLQILRDL
   121  SLLQIQMRDL EGYRETRYQL LQLRPAQRAS WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT
   181  SPDKVDYEYS ELLLYQNQVL REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL
   241  EDAADVYRGL QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF
   301  LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE TSLKSCRLFN
   361  PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA IESTPTLIEL FLVKAKIYKH
   421  AGNIKEAARW MDEAQALDTA DRFINSKCAK YMLKANLIKE AEEMCSKFTR EGTSAVENLN
   481  EMQCMWFQTE CAQAYKAMNK FGEALKKCHE IERHFIEITD DQFDFHTYCM RKITLRSYVD
   541  LLKLEDVLRQ HPFYFKAARI AIEIYLKLHD NPLTDENKEH EADTANMSDK ELKKLRNKQR
   601  RAQKKAQIEE EKKNAEKEKQ QRNQKKKKDD DDEEIGGPKE ELIPEKLAKV ETPLEEAIKF
   661  LTPLKNLVKN KIETHLFAFE IYFRKEKFLL MLQSVKRAFA IDSSHPWLHE CMIRLFNTAV
   721  CESKDLSDTV RTVLKQEMNR LFGATNPKNF NETFLKRNSD SLPHRLSAAK MVYYLDPSSQ
   781  KRAIELATTL DESLTNRNLQ TCMEVLEALY DGSLGDCKEA AEIYRANCHK LFPYALAFMP
   841  PGYEEDMKIT VNGDSSAEAE ELANEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
lymph node: 18 nTPM
tonsil: 18 nTPM
tongue: 17 nTPM
skeletal muscle: 17 nTPM
testis: 16 nTPM

Single-cell type

epicardial cells: 184 nCPM
myonuclei: 179 nCPM
erythrocyte progenitors: 177 nCPM
basal keratinocytes: 176 nCPM
endometrial ciliated cells: 168 nCPM
suprabasal keratinocytes: 164 nCPM

Immune cell

memory CD8 T-cell: 5.7 nTPM
naive CD8 T-cell: 5.5 nTPM
MAIT T-cell: 5.4 nTPM
T-reg: 5.2 nTPM
memory CD4 T-cell: 5 nTPM
naive CD4 T-cell: 4.8 nTPM

Brain region

cerebellum: 38 nTPM
white matter: 33 nTPM
cerebral cortex: 29 nTPM
medulla oblongata: 29 nTPM
midbrain: 29 nTPM
pons: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAA15.

Disease | AllUniProt

Conditions NAA15 is implicated in, by any mechanism.

Intellectual developmental disorder, autosomal dominant 50, with behavioral abnormalities (MRD50) MIM:617787

Disease | GeneticClinVar

167 pathogenic / likely-pathogenic of 666 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability, autosomal dominant 50
Inborn genetic diseases
NAA15-related disorder
Neurodevelopmental disorder
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 3.81
DepMap mean gene effect: -1.21
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA15 as an antibody target. Whether an autoantibody or antibody against NAA15 could matter depends on whether native NAA15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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