MCAT

Protein identityUniProt · HPA

UniProt accession

Q8IVS2

Gene

MCAT

Ensembl

ENSG00000100294

Chromosome

22

Canonical length

390 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q8IVS2|MCAT
     1  MSVRVARVAW VRGLGASYRR GASSFPVPPP GAQGVAELLR DATGAEEEAP WAATERRMPG
    61  QCSVLLFPGQ GSQVVGMGRG LLNYPRVREL YAAARRVLGY DLLELSLHGP QETLDRTVHC
   121  QPAIFVASLA AVEKLHHLQP SVIENCVAAA GFSVGEFAAL VFAGAMEFAE GLYAVKIRAE
   181  AMQEASEAVP SGMLSVLGQP QSKFNFACLE AREHCKSLGI ENPVCEVSNY LFPDCRVISG
   241  HQEALRFLQK NSSKFHFRRT RMLPVSGAFH TRLMEPAVEP LTQALKAVDI KKPLVSVYSN
   301  VHAHRYRHPG HIHKLLAQQL VSPVKWEQTM HAIYERKKGR GFPQTFEVGP GRQLGAILKS
   361  CNMQAWKSYS AVDVLQTLEH VDLDPQEPPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

24 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCAT.

Disease | AllUniProt

Conditions MCAT is implicated in, by any mechanism.

• Optic atrophy 15 (OPA15) MIM:620583

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 71 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Optic atrophy 15
• Acute myeloid leukemia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0

gnomAD missense Z

0.29

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fatty acid beta-oxidation
• fatty acid biosynthetic process
• mitochondrial small ribosomal subunit assembly

Molecular functions

• [acyl-carrier-protein] S-malonyltransferase activity
• RNA binding
• RNA folding chaperone

Cellular components

• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Acyl transferase domain superfamily
• Acyl transferase domain
• Acyl transferase/acyl hydrolase/lysophospholipase
• Malonyl-CoA ACP transacylase, ACP-binding
• Acyl transferase domain
• Mitochondrial malonyltransferase

KeywordsUniProt

• Fatty acid biosynthesis
• Fatty acid metabolism
• Lipid biosynthesis
• Lipid metabolism
• Mitochondrion
• Transferase
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of MCAT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MRPS16