Seroatlas · Human Serome Atlas

LIAT1

Protein LIAT1

Also known as: C17orf97, LIAT1_HUMAN, LOC400566

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZQX7
Gene
LIAT1
Ensembl
ENSG00000187624
Chromosome
17
Canonical length
453 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable molecular condensate scaffold activity. Predicted to be involved in membraneless organelle assembly and protein arginylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q6ZQX7|LIAT1
     1  METRGPGLAV RAESRRLVGI GPRAPPGRVG LQPSGRLDRR GGAGTMGYKD NDGEEEEREG
    61  GAAGPRGSRL PPITGGASEL AKRKVKKKKR KKKTKGSGKG DDKHQSQSLK SQPLSSSFHD
   121  ILSPCKERGP KPEHRQSKVE KKHLPSDSST VSLPDFAEIE NLANRINESL RWDGILADPE
   181  AEKERIRIYK LNRRKRYRCL ALKGFHPDPE ALKGFHPDPD ALKGFHPDPE ALKGFHPDPE
   241  ALKGFHPDPE ALKGFHPDPE ALKGIHPDPE ALKGIHPDPE ALKGFHPDPE ALKGFHPDPE
   301  ALKGFHTDPE ALKGFHIDPE ALKGFHPDPK ALKGFHPDPK ALKGFHTDPE ALKGFHPDPK
   361  ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE ALKGFHTDPN AEEAPENLPY LSDKDGSSSH
   421  RQPTSKAECP NLCFEGNLTP KLLHSDLAPT LLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • testis: 55 nTPM
  • basal ganglia: 9.6 nTPM
  • kidney: 9.2 nTPM
  • cerebral cortex: 8.1 nTPM
  • hypothalamus: 8 nTPM
  • fallopian tube: 6.9 nTPM

Single-cell type

  • late spermatids: 311 nCPM
  • early spermatids: 38 nCPM
  • ependymal cells: 30 nCPM
  • late primary spermatocytes: 24 nCPM
  • choroid plexus epithelial cells: 16 nCPM
  • brain inhibitory neurons: 11 nCPM

Immune cell

  • eosinophil: 0.5 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • choroid plexus: 9.1 nTPM
  • midbrain: 8.6 nTPM
  • cerebral cortex: 7.7 nTPM
  • medulla oblongata: 6.5 nTPM
  • basal ganglia: 6.1 nTPM
  • spinal cord: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein LIAT1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIAT1 as an antibody target. Whether an autoantibody or antibody against LIAT1 could matter depends on whether native LIAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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