Seroatlas · Human Serome Atlas

PLEKHF2

Pleckstrin homology domain-containing family F member 2

Also known as: FLJ13187, PHAFIN2, PKHF2_HUMAN, ZFYVE18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H8W4
Gene
PLEKHF2
Ensembl
ENSG00000175895
Chromosome
8
Canonical length
249 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endosome organization and endosome to lysosome transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q9H8W4|PLEKHF2
     1  MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP KARQFFLFND
    61  ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGDLRNGW LIKTPTKSFA VYAATATEKS
   121  EWMNHINKCV TDLLSKSGKT PSNEHAAVWV PDSEATVCMR CQKAKFTPVN RRHHCRKCGF
   181  VVCGPCSEKR FLLPSQSSKP VRICDFCYDL LSAGDMATCQ PARSDSYSQS LKSPLNDMSD
   241  DDDDDDSSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 97 nTPM
  • tonsil: 67 nTPM
  • lymph node: 59 nTPM
  • thymus: 29 nTPM
  • spleen: 25 nTPM
  • appendix: 24 nTPM

Single-cell type

  • neutrophils: 157 nCPM
  • b-cells: 116 nCPM
  • neutrophil progenitors: 116 nCPM
  • breast hormone-responsive cells: 100 nCPM
  • respiratory ionocytes: 99 nCPM
  • endometrial luminal cells: 94 nCPM

Immune cell

  • basophil: 124 nTPM
  • naive B-cell: 87 nTPM
  • memory B-cell: 78 nTPM
  • eosinophil: 48 nTPM
  • neutrophil: 33 nTPM
  • myeloid DC: 27 nTPM

Brain region

  • white matter: 16 nTPM
  • choroid plexus: 14 nTPM
  • spinal cord: 13 nTPM
  • medulla oblongata: 12 nTPM
  • cerebellum: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.87
gnomAD missense Z
1.88
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHF2 as an antibody target. Whether an autoantibody or antibody against PLEKHF2 could matter depends on whether native PLEKHF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLEKHF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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