MARK1

Protein identityUniProt · HPA

UniProt accession

Q9P0L2

Gene

MARK1

Ensembl

ENSG00000116141

Chromosome

1

Canonical length

795 aa

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

Enables several functions, including ATP binding activity; magnesium ion binding activity; and phospholipid binding activity. Involved in intracellular signal transduction; negative regulation of epithelial to mesenchymal transition; and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

795 residues, UniProt reviewed canonical sequence.

>Q9P0L2|MARK1
     1  MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY
    61  RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV
   121  KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH
   181  RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV
   241  WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG
   301  SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE
   361  VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR
   421  RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP
   481  ERKKSSTIPS NNVYSGGSMA RRNTYVCERT TDRYVALQNG KDSSLTEMSV SSISSAGSSV
   541  ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT TQRVPAASPS AHSISTATPD
   601  RTRFPRGSSS RSTFHGEQLR ERRSVAYNGP PASPSHETGA FAHARRGTST GIISKITSKF
   661  VRRDPSEGEA SGRTDTSRST SGEPKERDKE EGKDSKPRSL RFTWSMKTTS SMDPNDMMRE
   721  IRKVLDANNC DYEQKERFLL FCVHGDARQD SLVQWEMEVC KLPRLSLNGV RFKRISGTSI
   781  AFKNIASKIA NELKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

9.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.6

gnomAD missense Z

2.73

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoskeleton organization
• establishment of mitochondrion localization
• intracellular signal transduction
• microtubule cytoskeleton organization
• negative regulation of epithelial to mesenchymal transition
• negative regulation of gene expression
• neuron migration
• positive regulation of gene expression
• protein phosphorylation
• regulation of dendrite development
• regulation of neuron projection development
• regulation of postsynapse assembly
• Wnt signaling pathway

Molecular functions

• ATP binding
• magnesium ion binding
• phosphatidic acid binding
• phosphatidylinositol-4,5-bisphosphate binding
• phosphatidylserine binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• tau protein binding
• tau-protein kinase activity

Cellular components

• cytoplasm
• cytoskeleton
• dendrite
• glutamatergic synapse
• microtubule cytoskeleton
• plasma membrane
• postsynapse

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Kinase associated domain 1 (KA1)
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Ubiquitin-associated domain
• Protein kinase, ATP binding site
• KA1 domain/Ssp2, C-terminal
• Serine/threonine-protein kinase MARK 1-4, catalytic domain
• Protein kinase domain
• UBA/TS-N domain
• Kinase associated domain 1

KeywordsUniProt

• ATP-binding
• Autism
• Autism spectrum disorder
• Cell membrane
• Cell projection
• Cytoplasm
• Cytoskeleton
• Kinase
• Lipid-binding
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of MARK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAPT
• UTRN
• YWHAB
• YWHAE
• YWHAG
• YWHAZ