Seroatlas · Human Serome Atlas

MAPRE3

Microtubule-associated protein RP/EB family member 3

Also known as: EB3, MARE3_HUMAN, RP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPY8
Gene: MAPRE3
Ensembl: ENSG00000084764
Chromosome: 2
Canonical length: 281 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q9UPY8|MAPRE3
     1  MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM LFPGCVHLRK
    61  VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK FQDNFEFIQW FKKFFDANYD
   121  GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP
   181  PCILRKNPPS ARNGGHETDA QILELNQQLV DLKLTVDGLE KERDFYFSKL RDIELICQEH
   241  ESENSPVISG IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPRE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 161 nTPM
basal ganglia: 149 nTPM
cerebellum: 145 nTPM
hypothalamus: 144 nTPM
skeletal muscle: 140 nTPM
amygdala: 128 nTPM

Single-cell type

early spermatids: 554 nCPM
late spermatids: 402 nCPM
fallopian tube ciliated cells: 166 nCPM
respiratory ciliated cells: 154 nCPM
renal collecting duct intercalated cells: 105 nCPM
late primary spermatocytes: 100 nCPM

Immune cell

neutrophil: 3.5 nTPM
non-classical monocyte: 1.7 nTPM
intermediate monocyte: 1.4 nTPM
classical monocyte: 1.3 nTPM
myeloid DC: 0.8 nTPM
gdT-cell: 0.7 nTPM

Brain region

cerebral cortex: 205 nTPM
hypothalamus: 178 nTPM
basal ganglia: 166 nTPM
pons: 164 nTPM
hippocampal formation: 162 nTPM
medulla oblongata: 154 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.72
gnomAD missense Z: 2.36
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPRE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPRE3 as an antibody target. Whether an autoantibody or antibody against MAPRE3 could matter depends on whether native MAPRE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPRE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPRE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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