Seroatlas · Human Serome Atlas

TROAP

Tastin

Also known as: TASTIN, TROAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12815
Gene: TROAP
Ensembl: ENSG00000135451
Chromosome: 12
Canonical length: 778 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cell adhesion. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>Q12815|TROAP
     1  MTTRQATKDP LLRGVSPTPS KIPVRSQKRT PFPTVTSCAV DQENQDPRRW VQKPPLNIQR
    61  PLVDSAGPRP KARHQAETSQ RLVGISQPRN PLEELRPSPR GQNVGPGPPA QTEAPGTIEF
   121  VADPAALATI LSGEGVKSCH LGRQPSLAKR VLVRGSQGGT TQRVQGVRAS AYLAPRTPTH
   181  RLDPARASCF SRLEGPGPRG RTLCPQRLQA LISPSGPSFH PSTRPSFQEL RRETAGSSRT
   241  SVSQASGLLL ETPVQPAFSL PKGEREVVTH SDEGGVASLG LAQRVPLREN REMSHTRDSH
   301  DSHLMPSPAP VAQPLPGHVV PCPSPFGRAQ RVPSPGPPTL TSYSVLRRLT VQPKTRFTPM
   361  PSTPRVQQAQ WLRGVSPQSC SEDPALPWEQ VAVRLFDQES CIRSLEGSGK PPVATPSGPH
   421  SNRTPSLQEV KIQRIGILQQ LLRQEVEGLV GGQCVPLNGG SSLDMVELQP LLTEISRTLN
   481  ATEHNSGTSH LPGLLKHSGL PKPCLPEECG EPQPCPPAEP GPPEAFCRSE PEIPEPSLQE
   541  QLEVPEPYPP AEPRPLESCC RSEPEIPESS RQEQLEVPEP CPPAEPRPLE SYCRIEPEIP
   601  ESSRQEQLEV PEPCPPAEPG PLQPSTQGQS GPPGPCPRVE LGASEPCTLE HRSLESSLPP
   661  CCSQWAPATT SLIFSSQHPL CASPPICSLQ SLRPPAGQAG LSNLAPRTLA LRERLKSCLT
   721  AIHCFHEARL DDECAFYTSR APPSGPTRVC TNPVATLLEW QDALCFIPVG SAAPQGSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TROAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 48 nTPM
thymus: 34 nTPM
testis: 27 nTPM
tonsil: 14 nTPM
esophagus: 13 nTPM
lymph node: 11 nTPM

Single-cell type

late spermatids: 104 nCPM
late primary spermatocytes: 85 nCPM
gastric progenitor cells: 76 nCPM
early spermatids: 68 nCPM
esophageal basal cells: 50 nCPM
monocyte progenitors: 45 nCPM

Immune cell

T-reg: 8.7 nTPM
memory CD8 T-cell: 2.3 nTPM
memory CD4 T-cell: 2.1 nTPM
NK-cell: 2 nTPM
memory B-cell: 1.4 nTPM
naive B-cell: 1.4 nTPM

Brain region

thalamus: 1.7 nTPM
medulla oblongata: 1.6 nTPM
cerebral cortex: 1.5 nTPM
basal ganglia: 1.3 nTPM
pons: 1.2 nTPM
amygdala: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Tastin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TROAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TROAP as an antibody target. Whether an autoantibody or antibody against TROAP could matter depends on whether native TROAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TROAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TROAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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