Seroatlas · Human Serome Atlas

MAPRE2

Microtubule-associated protein RP/EB family member 2

Also known as: EB1, EB2, MARE2_HUMAN, RP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15555
Gene: MAPRE2
Ensembl: ENSG00000166974
Chromosome: 18
Canonical length: 327 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q15555|MAPRE2
     1  MPGPTQTLSP NGENNNDIIQ DNNGTIIPFR KHTVRGERSY SWGMAVNVYS TSITQETMSR
    61  HDIIAWVNDI VSLNYTKVEQ LCSGAAYCQF MDMLFPGCIS LKKVKFQAKL EHEYIHNFKL
   121  LQASFKRMNV DKVIPVEKLV KGRFQDNLDF IQWFKKFYDA NYDGKEYDPV EARQGQDAIP
   181  PPDPGEQIFN LPKKSHHANS PTAGAAKSSP AAKPGSTPSR PSSAKRASSS GSASKSDKDL
   241  ETQVIQLNEQ VHSLKLALEG VEKERDFYFG KLREIELLCQ EHGQENDDLV QRLMDILYAS
   301  EEHEGHTEEP EAEEQAHEQQ PPQQEEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPRE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 131 nTPM
cerebral cortex: 104 nTPM
tongue: 86 nTPM
heart muscle: 83 nTPM
thymus: 69 nTPM
midbrain: 67 nTPM

Single-cell type

nk-cells: 491 nCPM
myonuclei: 446 nCPM
retinal bipolar cells: 423 nCPM
oligodendrocytes: 400 nCPM
megakaryocyte-erythroid progenitors: 373 nCPM
retinal ganglion cells: 352 nCPM

Immune cell

total PBMC: 77 nTPM
NK-cell: 75 nTPM
basophil: 69 nTPM
gdT-cell: 64 nTPM
naive CD8 T-cell: 62 nTPM
memory B-cell: 61 nTPM

Brain region

white matter: 262 nTPM
cerebral cortex: 195 nTPM
medulla oblongata: 194 nTPM
pons: 188 nTPM
spinal cord: 185 nTPM
thalamus: 181 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAPRE2.

Disease | AllUniProt

Conditions MAPRE2 is implicated in, by any mechanism.

Skin creases, congenital symmetric circumferential, 2 (CSCSC2) MIM:616734

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 71 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Skin creases, congenital symmetric circumferential, 2
Developmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.83
gnomAD missense Z: 3.19
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPRE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPRE2 as an antibody target. Whether an autoantibody or antibody against MAPRE2 could matter depends on whether native MAPRE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPRE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPRE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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