Seroatlas · Human Serome Atlas

ZC2HC1A

Zinc finger C2HC domain-containing protein 1A

Also known as: C8orf70, CGI-62, FAM164A, ZC21A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GY0
Gene: ZC2HC1A
Ensembl: ENSG00000104427
Chromosome: 8
Canonical length: 325 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q96GY0|ZC2HC1A
     1  MEGLEENGGV VQVGELLPCK ICGRTFFPVA LKKHGPICQK TATKKRKTFD SSRQRAEGTD
    61  IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA LKEGGKLPPP PPPSYDPDYI
   121  QCPYCQRRFN ENAADRHINF CKEQAARISN KGKFSTDTKG KPTSRTQVYK PPALKKSNSP
   181  GTASSGSSRL PQPSGAGKTV VGVPSGKVSS SSSSLGNKLQ TLSPSHKGIA APHAGANVKP
   241  RNSTPPSLAR NPAPGVLTNK RKTYTESYIA RPDGDCASSL NGGNIKGIEG HSPGNLPKFC
   301  HECGTKYPVE WAKFCCECGI RRMIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC2HC1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 18 nTPM
thyroid gland: 15 nTPM
ovary: 15 nTPM
fallopian tube: 14 nTPM
endometrium: 13 nTPM
cerebellum: 12 nTPM

Single-cell type

respiratory ciliated cells: 249 nCPM
fallopian tube ciliated cells: 208 nCPM
lactotrophs: 183 nCPM
somatotrophs: 172 nCPM
ependymal cells: 141 nCPM
breast myoepithelial cells: 133 nCPM

Immune cell

basophil: 26 nTPM
T-reg: 20 nTPM
non-classical monocyte: 8.7 nTPM
memory B-cell: 5.2 nTPM
intermediate monocyte: 4.5 nTPM
classical monocyte: 4.1 nTPM

Brain region

cerebellum: 17 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 17 nTPM
pons: 17 nTPM
hypothalamus: 17 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.31
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC2HC1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC2HC1A as an antibody target. Whether an autoantibody or antibody against ZC2HC1A could matter depends on whether native ZC2HC1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC2HC1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC2HC1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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