Seroatlas · Human Serome Atlas

PSRC1

Proline/serine-rich coiled-coil protein 1

Also known as: DDA3, PSRC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PGN9
Gene: PSRC1
Ensembl: ENSG00000134222
Chromosome: 1
Canonical length: 363 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q6PGN9|PSRC1
     1  MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS DPNAVAPAPQ
    61  GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG EGLGPRRVKP SPRRETFVLK
   121  DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS NDRKGSVRAL RATSGKRPSN MKRESPTCNL
   181  FPASKSPASS PLTRSTPPVR GRAGPSGRAA ASEETRAAKL RVSGSGEFVG LTLKFLHPSP
   241  PGPPTPIRSV LAPQPSTSNS QRLPRPQGAA AKSSSQLPIP SAIPRPASRM PLTSRSVPPG
   301  RGALPPDSLS TRKGLPRPST AGHRVRESGH KVPVSQRLNL PVMGATRSNL QPPRKVAVPG
   361  PTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 91 nTPM
hippocampal formation: 64 nTPM
midbrain: 63 nTPM
cerebral cortex: 44 nTPM
retina: 39 nTPM
amygdala: 38 nTPM

Single-cell type

oligodendrocytes: 72 nCPM
peritubular myoid cells: 44 nCPM
rod photoreceptor cells: 40 nCPM
extravillous trophoblasts: 31 nCPM
migrating cytotrophoblasts: 30 nCPM
retinal pigment epithelial cells: 30 nCPM

Immune cell

classical monocyte: 12 nTPM
neutrophil: 7.2 nTPM
myeloid DC: 5.4 nTPM
intermediate monocyte: 4.8 nTPM
total PBMC: 3.5 nTPM
non-classical monocyte: 2.8 nTPM

Brain region

white matter: 114 nTPM
basal ganglia: 80 nTPM
medulla oblongata: 80 nTPM
midbrain: 74 nTPM
pons: 68 nTPM
cerebellum: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSRC1 as an antibody target. Whether an autoantibody or antibody against PSRC1 could matter depends on whether native PSRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...