Seroatlas · Human Serome Atlas

RNMT

mRNA cap guanine-N(7) methyltransferase

Also known as: MCES_HUMAN, N7-MTase, RG7MT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43148
Gene
RNMT
Ensembl
ENSG00000101654
Chromosome
18
Canonical length
476 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Enables RNA binding activity and mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap methyltransferase RNMT:RAMAC complex; mRNA capping enzyme complex; and receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>O43148|RNMT
     1  MANSAKAEEY EKMSLEQAKA SVNSETESSF NINENTTASG TGLSEKTSVC RQVDIARKRK
    61  EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG NSKKRKRETE DVPKDKSSTG
   121  DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA AHYNELQEVG LEKRSQSRIF YLRNFNNWMK
   181  SVLIGEFLEK VRQKKKRDIT VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY
   241  EDMKNRRDSE YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM
   301  LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD YPLFGCKYDF
   361  NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE EKIKNNENKM LLKRMQALEP
   421  YPANESSKLV SEKVDDYEHA AKYMKNSQVR LPLGTLSKSE WEATSIYLVF AFEKQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 41 nTPM
  • retina: 25 nTPM
  • choroid plexus: 22 nTPM
  • heart muscle: 19 nTPM
  • skeletal muscle: 17 nTPM
  • cerebral cortex: 16 nTPM

Single-cell type

  • esophageal apical cells: 252 nCPM
  • syncytiotrophoblasts: 171 nCPM
  • somatotrophs: 164 nCPM
  • b-cells: 150 nCPM
  • oocytes: 143 nCPM
  • pancreatic acinar cells: 140 nCPM

Immune cell

  • basophil: 45 nTPM
  • plasmacytoid DC: 30 nTPM
  • naive B-cell: 26 nTPM
  • memory B-cell: 24 nTPM
  • naive CD4 T-cell: 21 nTPM
  • T-reg: 19 nTPM

Brain region

  • choroid plexus: 41 nTPM
  • midbrain: 37 nTPM
  • pons: 36 nTPM
  • hypothalamus: 35 nTPM
  • cerebral cortex: 31 nTPM
  • white matter: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
-1.07
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • RNA binding
  • mRNA 5'-cap (guanine-N7-)-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNMT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNMT as an antibody target. Whether an autoantibody or antibody against RNMT could matter depends on whether native RNMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNMT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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