Seroatlas · Human Serome Atlas

KLC1

Kinesin light chain 1

Also known as: hKLC1B, hKLC1G, hKLC1J, hKLC1N, hKLC1P, hKLC1R, hKLC1S, KLC, KLC1_HUMAN, KNS2, KNS2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07866
Gene
KLC1
Ensembl
ENSG00000126214
Chromosome
14
Canonical length
573 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol,Acrosome,Equatorial segment

OverviewNCBI Gene

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named """"""""""""""""""""""""""""""""kinesin 2"""""""""""""""""""""""""""""""", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q07866|KLC1
     1  MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD
    61  ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL
   121  RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF
   181  PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL
   241  EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL
   301  NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY
   361  YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD
   421  DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF
   481  EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE
   541  EVSMSVEWNG GVSGRASFCG KRQQQQWPGR RHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
513 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 513 nTPM
  • cerebral cortex: 471 nTPM
  • spinal cord: 348 nTPM
  • midbrain: 332 nTPM
  • hypothalamus: 328 nTPM
  • hippocampal formation: 305 nTPM

Single-cell type

  • bergmann glia: 220 nCPM
  • other brain neurons: 179 nCPM
  • brain excitatory neurons: 160 nCPM
  • choroid plexus epithelial cells: 156 nCPM
  • astrocytes: 142 nCPM
  • brain inhibitory neurons: 135 nCPM

Immune cell

  • eosinophil: 10 nTPM
  • memory CD8 T-cell: 7.9 nTPM
  • plasmacytoid DC: 7.7 nTPM
  • gdT-cell: 7.5 nTPM
  • T-reg: 7.2 nTPM
  • naive B-cell: 6.9 nTPM

Brain region

  • pons: 599 nTPM
  • medulla oblongata: 450 nTPM
  • midbrain: 418 nTPM
  • cerebral cortex: 413 nTPM
  • spinal cord: 405 nTPM
  • hypothalamus: 401 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.37
gnomAD missense Z
3.22
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLC1 as an antibody target. Whether an autoantibody or antibody against KLC1 could matter depends on whether native KLC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...