Seroatlas · Human Serome Atlas

KLC2

Kinesin light chain 2

Also known as: FLJ12387, KLC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0B6
Gene
KLC2
Ensembl
ENSG00000174996
Chromosome
11
Canonical length
622 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Mitochondria,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q9H0B6|KLC2
     1  MAMMVFPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLVAPEAGEA EPGSQERCIL
    61  LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR RLVQENQWLR EELAGTQQKL
   121  QRSEQAVAQL EEEKQHLLFM SQIRKLDEDA SPNEEKGDVP KDTLDDLFPN EDEQSPAPSP
   181  GGGDVSGQHG GYEIPARLRT LHNLVIQYAS QGRYEVAVPL CKQALEDLEK TSGHDHPDVA
   241  TMLNILALVY RDQNKYKEAA HLLNDALAIR EKTLGKDHPA VAATLNNLAV LYGKRGKYKE
   301  AEPLCKRALE IREKVLGKFH PDVAKQLSNL ALLCQNQGKA EEVEYYYRRA LEIYATRLGP
   361  DDPNVAKTKN NLASCYLKQG KYQDAETLYK EILTRAHEKE FGSVNGDNKP IWMHAEEREE
   421  SKDKRRDSAP YGEYGSWYKA CKVDSPTVNT TLRSLGALYR RQGKLEAAHT LEDCASRNRK
   481  QGLDPASQTK VVELLKDGSG RRGDRRSSRD MAGGAGPRSE SDLEDVGPTA EWNGDGSGSL
   541  RRSGSFGKLR DALRRSSEML VKKLQGGTPQ EPPNPRMKRA SSLNFLNKSV EEPTQPGGTG
   601  LSDSRTLSSS SMDLSRRSSL VG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
147 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 147 nTPM
  • cerebral cortex: 98 nTPM
  • hippocampal formation: 56 nTPM
  • skeletal muscle: 54 nTPM
  • basal ganglia: 48 nTPM
  • hypothalamus: 47 nTPM

Single-cell type

  • brain excitatory neurons: 43 nCPM
  • early primary spermatocytes: 39 nCPM
  • other brain neurons: 31 nCPM
  • retinal horizontal cells: 30 nCPM
  • alveolar cells type 1: 29 nCPM
  • brain inhibitory neurons: 29 nCPM

Immune cell

  • naive B-cell: 3.2 nTPM
  • MAIT T-cell: 3.1 nTPM
  • gdT-cell: 2.4 nTPM
  • plasmacytoid DC: 2.1 nTPM
  • memory B-cell: 1.9 nTPM
  • memory CD8 T-cell: 1.6 nTPM

Brain region

  • cerebral cortex: 234 nTPM
  • pons: 156 nTPM
  • white matter: 144 nTPM
  • cerebellum: 141 nTPM
  • hippocampal formation: 129 nTPM
  • medulla oblongata: 121 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLC2.

Disease | AllUniProt

Conditions KLC2 is implicated in, by any mechanism.

  • Spastic paraplegia, optic atrophy, and neuropathy (SPOAN) MIM:609541

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 211 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spastic paraplegia, optic atropy, and neuropathy
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.98
gnomAD missense Z
2.02
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLC2 as an antibody target. Whether an autoantibody or antibody against KLC2 could matter depends on whether native KLC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...