Seroatlas · Human Serome Atlas

BORCS5

BLOC-1-related complex subunit 5

Also known as: BORC5_HUMAN, LOH12CR1, LOH1CR12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969J3
Gene
BORCS5
Ensembl
ENSG00000165714
Chromosome
12
Canonical length
196 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Involved in lysosome localization and organelle transport along microtubule. Located in cytoplasmic side of lysosomal membrane; plasma membrane; and plus-end kinesin complex. Part of BORC complex. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q969J3|BORCS5
     1  MGSEQSSEAE SRPNDLNSSV TPSPAKHRAK MDDIVVVAQG SQASRNVSND PDVIKLQEIP
    61  TFQPLLKGLL SGQTSPTNAK LEKLDSQQVL QLCLRYQDHL HQCAEAVAFD QNALVKRIKE
   121  MDLSVETLFS FMQERQKRYA KYAEQIQKVN EMSAILRRIQ MGIDQTVPLL DRLNSMLPEG
   181  ERLEPFSMKP DRELRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BORCS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 11 nTPM
  • spinal cord: 11 nTPM
  • midbrain: 10 nTPM
  • basal ganglia: 9.2 nTPM
  • hypothalamus: 9.1 nTPM
  • cerebral cortex: 8.8 nTPM

Single-cell type

  • oligodendrocytes: 144 nCPM
  • choroid plexus epithelial cells: 75 nCPM
  • podocytes: 73 nCPM
  • other brain neurons: 71 nCPM
  • brain inhibitory neurons: 68 nCPM
  • brain excitatory neurons: 60 nCPM

Immune cell

  • T-reg: 14 nTPM
  • NK-cell: 12 nTPM
  • MAIT T-cell: 12 nTPM
  • memory CD4 T-cell: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • intermediate monocyte: 10 nTPM

Brain region

  • white matter: 24 nTPM
  • basal ganglia: 22 nTPM
  • cerebral cortex: 22 nTPM
  • pons: 21 nTPM
  • hypothalamus: 20 nTPM
  • medulla oblongata: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BORCS5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • BORCS5-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • BLOC-1-related complex subunit 5
  • Tumour suppressor protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BORCS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BORCS5 as an antibody target. Whether an autoantibody or antibody against BORCS5 could matter depends on whether native BORCS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BORCS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BORCS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BORCS5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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