Seroatlas · Human Serome Atlas

KLC4

Kinesin light chain 4

Also known as: bA387M24.3, KLC4_HUMAN, KNSL8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSK0
Gene: KLC4
Ensembl: ENSG00000137171
Chromosome: 6
Canonical length: 619 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable kinesin binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q9NSK0|KLC4
     1  MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT IECLQQGGHE
    61  EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES EKQKLRAQVR RLCQENQWLR
   121  DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP
   181  NEEEEDPSNG LSRGQGATAA QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED
   241  LERTSGRGHP DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
   301  LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ GKYEAVERYY
   361  QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET LYKEILTRAH VQEFGSVDDD
   421  HKPIWMHAEE REEMSKSRHH EGGTPYAEYG GWYKACKVSS PTVNTTLRNL GALYRRQGKL
   481  EAAETLEECA LRSRRQGTDP ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE
   541  WSGDGSGTLQ RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
   601  PLQVSRGLSA STMDLSSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

liver: 87 nTPM
duodenum: 68 nTPM
small intestine: 60 nTPM
colon: 39 nTPM
rectum: 32 nTPM
cerebellum: 32 nTPM

Single-cell type

enterocytes: 177 nCPM
cardiomyocytes: 160 nCPM
hepatocytes: 106 nCPM
colonocytes: 104 nCPM
retinal ganglion cells: 70 nCPM
adipocytes: 66 nCPM

Immune cell

plasmacytoid DC: 8.8 nTPM
neutrophil: 6.6 nTPM
NK-cell: 4.9 nTPM
naive CD4 T-cell: 4.5 nTPM
T-reg: 4.5 nTPM
memory B-cell: 3.7 nTPM

Brain region

cerebellum: 31 nTPM
pons: 30 nTPM
white matter: 29 nTPM
cerebral cortex: 28 nTPM
medulla oblongata: 27 nTPM
thalamus: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLC4.

Disease | AllUniProt

Conditions KLC4 is implicated in, by any mechanism.

Neurodegeneration, early-childhood-onset, with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy (CONDRHN) MIM:621129

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 121 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Early-childhood-onset neurodegeneration with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule-based movement

Molecular functions

kinesin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLC4 as an antibody target. Whether an autoantibody or antibody against KLC4 could matter depends on whether native KLC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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