Seroatlas · Human Serome Atlas

CKAP2

Cytoskeleton-associated protein 2

Also known as: CKAP2_HUMAN, FLJ10749, LB1, se20-10, TMAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWK9
Gene: CKAP2
Ensembl: ENSG00000136108
Chromosome: 13
Canonical length: 683 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Mitotic spindle,Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>Q8WWK9|CKAP2
     1  MSTPAVPQDL QLPPSQRAQS AFKEQRRQKL KEHLLRRKTL FAYKQENEML SSSRDQRVVT
    61  SEDQVQEGTK VLKLKTKMAD KENMKRPAES KNNTVVGKHC IPLKPSNELT NSTVVIDTHK
   121  PKDSNQTPHL LLTEDDPQSQ HMTLSQAFHL KNNSKKKQMT TEKQKQDANM PKKPVLGSYR
   181  GQIVQSKINS FRKPLQVKDE SSAATKKLSA TIPKATKPQP VNTSSVTVKS NRSSNMTATT
   241  KFVSTTSQNT QLVRPPIRSH HSNTRDTVKQ GISRTSANVT IRKGPHEKEL LQSKTALSSV
   301  KTSSSQGIIR NKTLSRSIAS EVIARPASLS NDKLMEKSEP VDQRRHTAGK AIVDSRSAQP
   361  KETSEERKAR LSEWKAGKGR VLKRPPNSVV TQHEPAGQNE KPVGSFWTTM AEEDEQRLFT
   421  EKVNNTFSEC LNLINEGCPK EDILVTLNDL IKNIPDAKKL VKYWICLALI EPITSPIENI
   481  IAIYEKAILA GAQPIEEMRH TIVDILTMKS QEKANLGENM EKSCASKEEV KEVSIEDTGV
   541  DVDPEKLEME SKLHRNLLFQ DCEKEQDNKT KDPTHDVKTP NTETRTSCLI KYNVSTTPYL
   601  QSVKKKVQFD GTNSAFKELK FLTPVRRSRR LQEKTSKLPD MLKDHYPCVS SLEQLTELGR
   661  ETDAFVCRPN AALCRVYYEA DTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CKAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 64 nTPM
thymus: 31 nTPM
testis: 30 nTPM
tonsil: 19 nTPM
lymph node: 18 nTPM
skin: 13 nTPM

Single-cell type

early primary spermatocytes: 184 nCPM
monocyte progenitors: 141 nCPM
erythrocyte progenitors: 128 nCPM
late primary spermatocytes: 114 nCPM
megakaryocyte progenitors: 104 nCPM
granulosa cells: 92 nCPM

Immune cell

basophil: 86 nTPM
T-reg: 34 nTPM
naive B-cell: 33 nTPM
plasmacytoid DC: 33 nTPM
non-classical monocyte: 29 nTPM
memory B-cell: 25 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 16 nTPM
pons: 15 nTPM
medulla oblongata: 14 nTPM
hypothalamus: 13 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cytoskeleton-associated protein 2, C-terminal
Cytoskeleton-associated protein 2 C-terminus
Cytoskeleton-associated protein 2 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CKAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CKAP2 as an antibody target. Whether an autoantibody or antibody against CKAP2 could matter depends on whether native CKAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CKAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CKAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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