Seroatlas · Human Serome Atlas

INTS3

Integrator complex subunit 3

Also known as: C1orf60, FLJ21919, INT3, INT3_HUMAN, SOSS-A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68E01
Gene: INTS3
Ensembl: ENSG00000143624
Chromosome: 1
Canonical length: 1043 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

1043 residues, UniProt reviewed canonical sequence.

>Q68E01|INTS3
     1  MELQKGKGAA AAAAASGAAG GGGGGAGAGA PGGGRLLLST SLDAKDELEE RLERCMSIVT
    61  SMTAGVSERE ANDALNAYVC KGLPQHEEIC LGLFTLILTE PAQAQKCYRD LALVSRDGMN
   121  IVLNKINQIL MEKYLKLQDT CRTQLVWLVR ELVKSGVLGA DGVCMTFMKQ IAGGGDVTAK
   181  NIWLAESVLD ILTEQREWVL KSSILIAMAV YTYLRLIVDH HGTAQLQALR QKEVDFCISL
   241  LRERFMECLM IGRDLVRLLQ NVARIPEFEL LWKDIIHNPQ ALSPQFTGIL QLLQSRTSRK
   301  FLACRLTPDM ETKLLFMTSR VRFGQQKRYQ DWFQRQYLST PDSQSLRCDL IRYICGVVHP
   361  SNEVLSSDIL PRWAIIGWLL TTCTSNVAAS NAKLALFYDW LFFSPDKDSI MNIEPAILVM
   421  HHSMKPHPAI TATLLDFMCR IIPNFYPPLE GHVRQGVFSS LNHIVEKRVL AHLAPLFDNP
   481  KLDKELRAML REKFPEFCSS PSPPVEVKIE EPVSMEMDNH MSDKDESCYD NAEAAFSDDE
   541  EDLNSKGKKR EFRFHPIKET VVEEPVDITP YLDQLDESLR DKVLQLQKGS DTEAQCEVMQ
   601  EIVDQVLEED FDSEQLSVLA SCLQELFKAH FRGEVLPEEI TEESLEESVG KPLYLIFRNL
   661  CQMQEDNSSF SLLLDLLSEL YQKQPKIGYH LLYYLRASKA AAGKMNLYES FAQATQLGDL
   721  HTCLMMDMKA CQEDDVRLLC HLTPSIYTEF PDETLRSGEL LNMIVAVIDS AQLQELVCHV
   781  MMGNLVMFRK DSVLNILIQS LDWETFEQYC AWQLFLAHNI PLETIIPILQ HLKYKEHPEA
   841  LSCLLLQLRR EKPSEEMVKM VLSRPCHPDD QFTTSILRHW CMKHDELLAE HIKSLLIKNN
   901  SLPRKRQSLR SSSSKLAQLT LEQILEHLDN LRLNLTNTKQ NFFSQTPILQ ALQHVQASCD
   961  EAHKMKFSDL FSLAEEYEDS STKPPKSRRK AALSSPRSRK NATQPPNAEE ESGSSSASEE
  1021  EDTKPKPTKR KRKGSSAVGS DSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

ovary: 19 nTPM
fallopian tube: 18 nTPM
blood vessel: 18 nTPM
endometrium: 16 nTPM
adrenal gland: 16 nTPM
kidney: 16 nTPM

Single-cell type

podocytes: 100 nCPM
proximal tubule cells: 83 nCPM
astrocytes: 78 nCPM
ependymal cells: 63 nCPM
loop of henle epithelial cells: 60 nCPM
bergmann glia: 58 nCPM

Immune cell

non-classical monocyte: 2.9 nTPM
myeloid DC: 1.2 nTPM
eosinophil: 0.9 nTPM
gdT-cell: 0.9 nTPM
classical monocyte: 0.8 nTPM
MAIT T-cell: 0.8 nTPM

Brain region

hypothalamus: 24 nTPM
medulla oblongata: 21 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 19 nTPM
hippocampal formation: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 4.41
DepMap mean gene effect: -1.51
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integrator complex subunit 3, N-terminal
Integrator complex subunit 3
Ints3-like, C-terminal
Integrator complex subunit 3 N-terminal
Ints3-like, C-terminal HEAT repeats

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS3 as an antibody target. Whether an autoantibody or antibody against INTS3 could matter depends on whether native INTS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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