Seroatlas · Human Serome Atlas

INTS14

Integrator complex subunit 14

Also known as: C15orf44, DKFZP564O1664, INT14_HUMAN, VWA9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96SY0
Gene
INTS14
Ensembl
ENSG00000138614
Chromosome
15
Canonical length
518 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nuclear bodies,Mitochondria

OverviewNCBI Gene

Predicted to be involved in snRNA 3'-end processing. Located in cytoplasm. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q96SY0|INTS14
     1  MPTVVVMDVS LSMTRPVSIE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF TALVVFSSLW
    61  ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ QEWGGAIPCQ VVLVTDGCLG
   121  IGRGSLRHSL ATQNQRSESN RFPLPFPFPS KLYIMCMANL EELQSTDSLE CLERLIDLNN
   181  GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTADVQVFPR PEPFVVDEEI
   241  DPIPKVINTD LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGIT DDNEDENSAN
   301  QIAGKIPNFC VLLHGSLKVE GMVAIVQLGP EWHGMLYSQA DSKKKSNLMM SLFEPGPEPL
   361  PWLGKMAQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
   421  RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPET AHPDAAFQLT
   481  HAAQQLKLAS TGTSEYAAYD QNITPLHTDF SGSSTERI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 28 nTPM
  • thymus: 25 nTPM
  • tonsil: 25 nTPM
  • fallopian tube: 25 nTPM
  • rectum: 24 nTPM
  • thyroid gland: 24 nTPM

Single-cell type

  • early primary spermatocytes: 66 nCPM
  • syncytiotrophoblasts: 63 nCPM
  • epididymal basal cells: 55 nCPM
  • cytotrophoblasts: 53 nCPM
  • differentiating spermatogonia: 47 nCPM
  • migrating cytotrophoblasts: 47 nCPM

Immune cell

  • T-reg: 34 nTPM
  • basophil: 30 nTPM
  • NK-cell: 26 nTPM
  • MAIT T-cell: 26 nTPM
  • memory CD8 T-cell: 25 nTPM
  • naive CD4 T-cell: 24 nTPM

Brain region

  • choroid plexus: 26 nTPM
  • white matter: 24 nTPM
  • thalamus: 22 nTPM
  • basal ganglia: 21 nTPM
  • hypothalamus: 20 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS14 as an antibody target. Whether an autoantibody or antibody against INTS14 could matter depends on whether native INTS14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INTS14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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