Seroatlas · Human Serome Atlas

INTS9

Integrator complex subunit 9

Also known as: CPSF2L, FLJ10871, INT9_HUMAN, RC-74

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV88
Gene: INTS9
Ensembl: ENSG00000104299
Chromosome: 8
Canonical length: 658 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

658 residues, UniProt reviewed canonical sequence.

>Q9NV88|INTS9
     1  MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS NLPGWSLKDG
    61  NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL ISNYHCMMAL PYITEHTGFT
   121  GTVYATEPTV QIGRLLMEEL VNFIERVPKA QSASLWKNKD IQRLLPSPLK DAVEVSTWRR
   181  CYTMQEVNSA LSKIQLVGYS QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS
   241  SLLTTHPQPM DQASLKNSDV LVLTGLTQIP TANPDGMVGE FCSNLALTVR NGGNVLVPCY
   301  PSGVIYDLLE CLYQYIDSAG LSSVPLYFIS PVANSSLEFS QIFAEWLCHN KQSKVYLPEP
   361  PFPHAELIQT NKLKHYPSIH GDFSNDFRQP CVVFTGHPSL RFGDVVHFME LWGKSSLNTV
   421  IFTEPDFSYL EALAPYQPLA MKCIYCPIDT RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP
   481  AQSHRMDLMI DCQPPAMSYR RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV
   541  SAVLHTKDNK HLLQPPPRPA QPTSGKKRKR VSDDVPDCKV LKPLLSGSIP VEQFVQTLEK
   601  HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND EMLRVRLRDL VLKFLQKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 21 nTPM
tonsil: 17 nTPM
thymus: 16 nTPM
choroid plexus: 16 nTPM
spleen: 15 nTPM
lymph node: 14 nTPM

Single-cell type

adrenal cortex cells: 184 nCPM
rod photoreceptor cells: 137 nCPM
renal collecting duct intercalated cells: 115 nCPM
sertoli cells: 105 nCPM
pituicytes/fscs: 94 nCPM
cone photoreceptor cells: 89 nCPM

Immune cell

myeloid DC: 29 nTPM
NK-cell: 25 nTPM
intermediate monocyte: 23 nTPM
classical monocyte: 21 nTPM
T-reg: 20 nTPM
naive B-cell: 20 nTPM

Brain region

choroid plexus: 13 nTPM
white matter: 9.8 nTPM
thalamus: 9.3 nTPM
basal ganglia: 9 nTPM
midbrain: 8.9 nTPM
cerebellum: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -1.69
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Metallo-beta-lactamase
Beta-Casp domain
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Beta-Casp domain
Metallo-beta-lactamase superfamily domain
Integrator complex subunit 9
Integrator complex subunit 9-like, C-terminal domain
Integrator IntS9, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS9 as an antibody target. Whether an autoantibody or antibody against INTS9 could matter depends on whether native INTS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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