Seroatlas · Human Serome Atlas

NABP1

SOSS complex subunit B2

Also known as: DKFZp667M1322, FLJ13624, FLJ22833, hSSB2, MGC111163, NABP1-OT1, OBFC2A, SOSB2_HUMAN, SOSS-B2, SSB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AH0
Gene: NABP1
Ensembl: ENSG00000173559
Chromosome: 2
Canonical length: 204 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q96AH0|NABP1
     1  MNRVNDPLIF IRDIKPGLKN LNVVFIVLEI GRVTKTKDGH EVRSCKVADK TGSITISVWD
    61  EIGGLIQPGD IIRLTRGYAS MWKGCLTLYT GRGGELQKIG EFCMVYSEVP NFSEPNPDYR
   121  GQQNKGAQSE QKNNSMNSNM GTGTFGPVGN GVHTGPESRE HQFSHAGRSN GRGLINPQLQ
   181  GTASNQTVMT TISNGRDPRR AFKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NABP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

appendix: 22 nTPM
spleen: 20 nTPM
small intestine: 18 nTPM
urinary bladder: 17 nTPM
adipose tissue: 14 nTPM
lung: 14 nTPM

Single-cell type

neutrophils: 2,644 nCPM
endometrial glandular cells: 550 nCPM
epididymal basal cells: 442 nCPM
cdc: 390 nCPM
early spermatids: 356 nCPM
esophageal apical cells: 338 nCPM

Immune cell

neutrophil: 39 nTPM
T-reg: 29 nTPM
non-classical monocyte: 22 nTPM
basophil: 20 nTPM
MAIT T-cell: 19 nTPM
memory CD4 T-cell: 17 nTPM

Brain region

thalamus: 11 nTPM
choroid plexus: 10 nTPM
white matter: 7.5 nTPM
medulla oblongata: 5.8 nTPM
midbrain: 5.8 nTPM
hypothalamus: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NABP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

INTS3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NABP1 as an antibody target. Whether an autoantibody or antibody against NABP1 could matter depends on whether native NABP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NABP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NABP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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