Seroatlas · Human Serome Atlas

KCNAB1

Voltage-gated potassium channel subunit beta-1

Also known as: AKR6A3, hKvb3, hKvBeta3, KCAB1_HUMAN, KCNA1B, Kvb1.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14722
Gene
KCNAB1
Ensembl
ENSG00000169282
Chromosome
3
Canonical length
419 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane
Quaternary structure
Homotetramer

OverviewNCBI Gene

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q14722|KCNAB1
     1  MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL
    61  ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV
   121  AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE
   181  RGLSRKHIIE GLKGSLQRLQ LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS
   241  RWSAMEIMEA YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC
   301  GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER LGCTLPQLAV
   361  AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV NEIDNILRNK PYSKKDYRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNAB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 92 nTPM
  • basal ganglia: 61 nTPM
  • thyroid gland: 27 nTPM
  • prostate: 21 nTPM
  • hippocampal formation: 21 nTPM
  • seminal vesicle: 18 nTPM

Single-cell type

  • vascular smooth muscle cells: 168 nCPM
  • gonadotrophs: 48 nCPM
  • early spermatids: 46 nCPM
  • pericytes: 37 nCPM
  • medullary thymic epithelial cells: 29 nCPM
  • oligodendrocytes: 26 nCPM

Immune cell

  • plasmacytoid DC: 1.2 nTPM
  • basophil: 0.8 nTPM
  • MAIT T-cell: 0.8 nTPM
  • T-reg: 0.5 nTPM
  • gdT-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM

Brain region

  • basal ganglia: 111 nTPM
  • hippocampal formation: 56 nTPM
  • cerebellum: 34 nTPM
  • white matter: 33 nTPM
  • cerebral cortex: 32 nTPM
  • hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.04
gnomAD missense Z
2.15
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNAB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNAB1 as an antibody target. Whether an autoantibody or antibody against KCNAB1 could matter depends on whether native KCNAB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNAB1 is annotated at the cell surface, where native KCNAB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNAB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNAB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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