Seroatlas · Human Serome Atlas

DNAJA4

DnaJ homolog subfamily A member 4

Also known as: DNJA4_HUMAN, PRO1472

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW22
Gene: DNAJA4
Ensembl: ENSG00000140403
Chromosome: 15
Canonical length: 397 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Plasma membrane,Primary cilium,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

Enables protein-folding chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q8WW22|DNAJA4
     1  MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ AYEVLSDPKK
    61  RDVYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMA RERRGKNVVH QLSVTLEDLY
   121  NGVTKKLALQ KNVICEKCEG VGGKKGSVEK CPLCKGRGMQ IHIQQIGPGM VQQIQTVCIE
   181  CKGQGERINP KDRCESCSGA KVIREKKIIE VHVEKGMKDG QKILFHGEGD QEPELEPGDV
   241  IIVLDQKDHS VFQRRGHDLI MKMKIQLSEA LCGFKKTIKT LDNRILVITS KAGEVIKHGD
   301  LRCVRDEGMP IYKAPLEKGI LIIQFLVIFP EKHWLSLEKL PQLEALLPPR QKVRITDDMD
   361  QVELKEFCPN EQNWRQHREA YEEDEDGPQA GVQCQTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 135 nTPM

Expression across tissuesHPA

Tissue

tongue: 135 nTPM
skeletal muscle: 115 nTPM
heart muscle: 115 nTPM
hypothalamus: 76 nTPM
testis: 75 nTPM
cerebral cortex: 70 nTPM

Single-cell type

late spermatids: 2,212 nCPM
early spermatids: 842 nCPM
epididymal efferent duct absorptive cells: 495 nCPM
epididymal efferent duct ciliated cells: 416 nCPM
respiratory ciliated cells: 268 nCPM
breast lactating cells: 260 nCPM

Immune cell

naive CD4 T-cell: 1.7 nTPM
naive CD8 T-cell: 1.4 nTPM
eosinophil: 1.2 nTPM
MAIT T-cell: 1 nTPM
memory CD4 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.9 nTPM

Brain region

hypothalamus: 148 nTPM
pons: 142 nTPM
cerebral cortex: 126 nTPM
midbrain: 106 nTPM
white matter: 97 nTPM
thalamus: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJA4 as an antibody target. Whether an autoantibody or antibody against DNAJA4 could matter depends on whether native DNAJA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJA4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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