Seroatlas · Human Serome Atlas

PEX11A

Peroxisomal membrane protein 11A

Also known as: MGC119947, MGC138534, PEX11alpha, PMP28, PX11A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75192
Gene
PEX11A
Ensembl
ENSG00000166821
Chromosome
15
Canonical length
247 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>O75192|PEX11A
     1  MDAFTRFTNQ TQGRDRLFRA TQYTCMLLRY LLEPKAGKEK VVMKLKKLES SVSTGRKWFR
    61  LGNVVHAIQA TEQSIHATDL VPRLCLTLAN LNRVIYFICD TILWVRSVGL TSGINKEKWR
   121  TRAAHHYYYS LLLSLVRDLY EISLQMKRVT CDRAKKEKSA SQDPLWFSVA EEETEWLQSF
   181  LLLLFRSLKQ HPPLLLDTVK NLCDILNPLD QLGIYKSNPG IIGLGGLVSS IAGMITVAYP
   241  QMKLKTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • liver: 37 nTPM
  • adipose tissue: 24 nTPM
  • breast: 19 nTPM
  • prostate: 17 nTPM
  • skeletal muscle: 17 nTPM
  • duodenum: 15 nTPM

Single-cell type

  • late spermatids: 60 nCPM
  • prostatic club cells: 57 nCPM
  • adipocytes: 50 nCPM
  • hepatocytes: 48 nCPM
  • late primary spermatocytes: 42 nCPM
  • prostatic hillock cells: 39 nCPM

Immune cell

  • gdT-cell: 3.6 nTPM
  • NK-cell: 3 nTPM
  • naive CD8 T-cell: 2.6 nTPM
  • eosinophil: 2.3 nTPM
  • naive CD4 T-cell: 2.2 nTPM
  • MAIT T-cell: 2 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • hypothalamus: 13 nTPM
  • basal ganglia: 11 nTPM
  • midbrain: 11 nTPM
  • thalamus: 11 nTPM
  • amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX11A as an antibody target. Whether an autoantibody or antibody against PEX11A could matter depends on whether native PEX11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX11A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PEX11A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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