PLK2

Protein identityUniProt · HPA

UniProt accession

Q9NYY3

Gene

PLK2

Ensembl

ENSG00000145632

Chromosome

5

Canonical length

685 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

685 residues, UniProt reviewed canonical sequence.

>Q9NYY3|PLK2
     1  MELLRTITYQ PAASTKMCEQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAAPHHHH
    61  HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK
   121  PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP
   181  EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI
   241  CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP
   301  SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA
   361  KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEDIYKLRH DLKKTSITQQ PSKHRTDEEL
   421  QPPTTTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR
   481  GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD
   541  KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDIRRPRL
   601  YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL
   661  LMSGCSSELK NRMEYALNML LQRCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

84 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLK2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hereditary breast ovarian cancer syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.18

gnomAD pLI

1

gnomAD missense Z

3.01

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA damage response, signal transduction by p53 class mediator
• G1/S transition of mitotic cell cycle
• long-term synaptic depression
• long-term synaptic potentiation
• memory
• mitotic spindle organization
• negative regulation of angiogenesis
• negative regulation of apoptotic process
• negative regulation of apoptotic process in bone marrow cell
• negative regulation of cellular senescence
• negative regulation of inflammatory response to antigenic stimulus
• positive regulation of autophagy
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of cell migration involved in sprouting angiogenesis
• positive regulation of protein catabolic process
• protein phosphorylation
• Rap protein signal transduction
• Ras protein signal transduction
• regulation of centriole replication
• regulation of synaptic plasticity

Molecular functions

• ATP binding
• ATP-dependent protein binding
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• centriole
• centrosome
• chromatin
• cytoplasm
• cytosol
• dendrite
• kinetochore
• nucleus
• spindle pole

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• POLO box domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Second polo-box domain
• First polo-box domain
• POLO box domain superfamily
• Protein kinase domain
• POLO box duplicated region
• PLK2, catalytic domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Cytoplasm
• Cytoskeleton
• Kinase
• Nucleotide-binding
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• Transferase
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of PLK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CIB1
• NSF