ITGA2B

Protein identityUniProt · HPA

UniProt accession

P08514

Gene

ITGA2B

Ensembl

ENSG00000005961

Chromosome

17

Canonical length

1039 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

1039 residues, UniProt reviewed canonical sequence.

>P08514|ITGA2B
     1  MARALCPLQA LWLLEWVLLL LGPCAAPPAW ALNLDPVQLT FYAGPNGSQF GFSLDFHKDS
    61  HGRVAIVVGA PRTLGPSQEE TGGVFLCPWR AEGGQCPSLL FDLRDETRNV GSQTLQTFKA
   121  RQGLGASVVS WSDVIVACAP WQHWNVLEKT EEAEKTPVGS CFLAQPESGR RAEYSPCRGN
   181  TLSRIYVEND FSWDKRYCEA GFSSVVTQAG ELVLGAPGGY YFLGLLAQAP VADIFSSYRP
   241  GILLWHVSSQ SLSFDSSNPE YFDGYWGYSV AVGEFDGDLN TTEYVVGAPT WSWTLGAVEI
   301  LDSYYQRLHR LRGEQMASYF GHSVAVTDVN GDGRHDLLVG APLYMESRAD RKLAEVGRVY
   361  LFLQPRGPHA LGAPSLLLTG TQLYGRFGSA IAPLGDLDRD GYNDIAVAAP YGGPSGRGQV
   421  LVFLGQSEGL RSRPSQVLDS PFPTGSAFGF SLRGAVDIDD NGYPDLIVGA YGANQVAVYR
   481  AQPVVKASVQ LLVQDSLNPA VKSCVLPQTK TPVSCFNIQM CVGATGHNIP QKLSLNAELQ
   541  LDRQKPRQGR RVLLLGSQQA GTTLNLDLGG KHSPICHTTM AFLRDEADFR DKLSPIVLSL
   601  NVSLPPTEAG MAPAVVLHGD THVQEQTRIV LDCGEDDVCV PQLQLTASVT GSPLLVGADN
   661  VLELQMDAAN EGEGAYEAEL AVHLPQGAHY MRALSNVEGF ERLICNQKKE NETRVVLCEL
   721  GNPMKKNAQI GIAMLVSVGN LEEAGESVSF QLQIRSKNSQ NPNSKIVLLD VPVRAEAQVE
   781  LRGNSFPASL VVAAEEGERE QNSLDSWGPK VEHTYELHNN GPGTVNGLHL SIHLPGQSQP
   841  SDLLYILDIQ PQGGLQCFPQ PPVNPLKVDW GLPIPSPSPI HPAHHKRDRR QIFLPEPEQP
   901  SRLQDPVLVS CDSAPCTVVQ CDLQEMARGQ RAMVTVLAFL WLPSLYQRPL DQFVLQSHAW
   961  FNVSSLPYAV PPLSLPRGEA QVWTQLLRAL EERAIPIWWV LVGVLGGLLL LTILVLAMWK
  1021  VGFFKRNRPP LEEDDEEGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

16 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ITGA2B.

Disease | AllUniProt

Conditions ITGA2B is implicated in, by any mechanism.

• Fetomaternal alloimmune thrombocytopenia 2 (FMAIT2) MIM:621266
• Glanzmann thrombasthenia 1 (GT1) MIM:273800
• Bleeding disorder, platelet-type, 16 (BDPLT16) MIM:187800

Disease | GeneticClinVar

255 pathogenic / likely-pathogenic of 997 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Glanzmann thrombasthenia
• Glanzmann thrombasthenia 1
• Platelet-type bleeding disorder 16
• ITGA2B-related disorder
• Macrothrombocytopenia

Disease | ImmuneIEDB

Conditions an epitope on ITGA2B was assayed in.

• autoimmune thrombocytopenic purpura B and T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against ITGA2B are reported. Each links to that disease's full target list.

• Thrombocytopenia 3

ReferencesPubMed · IEDB

Publications for ITGA2B from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.76

gnomAD pLI

0

gnomAD missense Z

1.23

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• cell-cell adhesion
• cell-matrix adhesion
• integrin-mediated signaling pathway
• positive regulation of leukocyte migration

Molecular functions

• extracellular matrix binding
• fibrinogen binding
• identical protein binding
• metal ion binding
• molecular adaptor activity
• signaling receptor activity

Cellular components

• blood microparticle
• cell surface
• external side of plasma membrane
• extracellular exosome
• focal adhesion
• integrin alphaIIb-beta3 complex
• plasma membrane
• platelet alpha granule membrane

Protein domainsUniProt · Pfam · InterPro

• Integrin alpha chain
• FG-GAP repeat
• Integrin alpha beta-propellor
• Integrin alpha, first immunoglubulin-like domain
• Integrin alpha chain, C-terminal cytoplasmic region, conserved site
• Integrin alpha, N-terminal
• Integrin domain superfamily
• Integrin alpha, second immunoglobulin-like domain
• Integrin alpha, third immunoglobulin-like domain
• Integrin alpha cytoplasmic region
• FG-GAP repeat
• Integrin alpha Ig-like domain 1
• Integrin alpha Ig-like domain 2
• Integrin alpha Ig-like domain 3

KeywordsUniProt

• Calcium
• Cell adhesion
• Cell membrane
• Cleavage on pair of basic residues
• Disulfide bond
• Glycoprotein
• Integrin
• Membrane
• Metal-binding
• Pyrrolidone carboxylic acid
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ITGA2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RNF181
• SELP
• CIB2
• CIB3
• CIB1
• CIB4
• ITGB3