Seroatlas · Human Serome Atlas

PPP3R1

Calcineurin subunit B type 1

Also known as: CALNB1, CANB1_HUMAN, CNB, CNB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63098
Gene: PPP3R1
Ensembl: ENSG00000221823
Chromosome: 2
Canonical length: 170 aa
Protein class: FDA approved drug targets, Predicted intracellular proteins
Subcellular location: Plasma membrane,Primary cilium,Cytosol

OverviewNCBI Gene

Enables phosphatase binding activity and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>P63098|PPP3R1
     1  MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID
    61  IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV
   121  GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP3R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

retina: 176 nTPM
cerebral cortex: 154 nTPM
basal ganglia: 128 nTPM
hippocampal formation: 111 nTPM
cerebellum: 96 nTPM
skeletal muscle: 83 nTPM

Single-cell type

megakaryocytes: 25 nCPM
platelets: 18 nCPM
early spermatids: 12 nCPM
megakaryocyte progenitors: 8.7 nCPM
rod photoreceptor cells: 8.1 nCPM
late primary spermatocytes: 7.2 nCPM

Immune cell

neutrophil: 2.7 nTPM
basophil: 1.5 nTPM
eosinophil: 1.3 nTPM
plasmacytoid DC: 0.7 nTPM
non-classical monocyte: 0.6 nTPM
classical monocyte: 0.5 nTPM

Brain region

cerebral cortex: 345 nTPM
hippocampal formation: 292 nTPM
basal ganglia: 279 nTPM
white matter: 214 nTPM
amygdala: 166 nTPM
cerebellum: 164 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.41
gnomAD missense Z: 2.89
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP3R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP3R1 as an antibody target. Whether an autoantibody or antibody against PPP3R1 could matter depends on whether native PPP3R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP3R1 is annotated at the cell surface, where native PPP3R1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PPP3R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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