Seroatlas · Human Serome Atlas

CEP152

Centrosomal protein of 152 kDa

Also known as: CE152_HUMAN, KIAA0912, MCPH9, SCKL5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94986
Gene: CEP152
Ensembl: ENSG00000103995
Chromosome: 15
Canonical length: 1710 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Basal body

OverviewNCBI Gene

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

1710 residues, UniProt reviewed canonical sequence.

>O94986|CEP152
     1  MSLDFGSVAL PVQNEDEEYD EEDYEREKEL QQLLTDLPHD MLDDDLSSPE LQYSDCSEDG
    61  TDGQPHHPEQ LEMSWNEQML PKSQSVNGYN EIQSLYAGEK CGNVWEENRS KTEDRHPVYH
   121  PEEGGDEGGS GYSPPSKCEQ TDLYHLPENF RPYTNGQKQE FNNQATNVIK FSDPQWNHFQ
   181  GPSCQGLEPY NKVTYKPYQS SAQNNGSPAQ EITGSDTFEG LQQQFLGANE NSAENMQIIQ
   241  LQVLNKAKER QLENLIEKLN ESERQIRYLN HQLVIIKDEK DGLTLSLRES QKLFQNGKER
   301  EIQLEAQIKA LETQIQALKV NEEQMIKKSR TTEMALESLK QQLVDLHHSE SLQRAREQHE
   361  SIVMGLTKKY EEQVLSLQKN LDATVTALKE QEDICSRLKD HVKQLERNQE AIKLEKTEII
   421  NKLTRSLEES QKQCAHLLQS GSVQEVAQLQ FQLQQAQKAH AMSANMNKAL QEELTELKDE
   481  ISLYESAAKL GIHPSDSEGE LNIELTESYV DLGIKKVNWK KSKVTSIVQE EDPNEELSKD
   541  EFILKLKAEV QRLLGSNSMK RHLVSQLQND LKDCHKKIED LHQVKKDEKS IEVETKTDTS
   601  EKPKNQLWPE SSTSDVVRDD ILLLKNEIQV LQQQNQELKE TEGKLRNTNQ DLCNQMRQMV
   661  QDFDHDKQEA VDRCERTYQQ HHEAMKTQIR ESLLAKHALE KQQLFEAYER THLQLRSELD
   721  KLNKEVTAVQ ECYLEVCREK DNLELTLRKT TEKEQQTQEK IKEKLIQQLE KEWQSKLDQT
   781  IKAMKKKTLD CGSQTDQVTT SDVISKKEMA IMIEEQKCTI QQNLEQEKDI AIKGAMKKLE
   841  IELELKHCEN ITKQVEIAVQ NAHQRWLGEL PELAEYQALV KAEQKKWEEQ HEVSVNKRIS
   901  FAVSEAKEKW KSELENMRKN ILPGKELEEK IHSLQKELEL KNEEVPVVIR AELAKARSEW
   961  NKEKQEEIHR IQEQNEQDYR QFLDDHRNKI NEVLAAAKED FMKQKTELLL QKETELQTCL
  1021  DQSRREWTMQ EAKRIQLEIY QYEEDILTVL GVLLSDTQKE HISDSEDKQL LEIMSTCSSK
  1081  WMSVQYFEKL KGCIQKAFQD TLPLLVENAD PEWKKRNMAE LSKDSASQGT GQGDPGPAAG
  1141  HHAQPLALQA TEAEADKKKV LEIKDLCCGH CFQELEKAKQ ECQDLKGKLE KCCRHLQHLE
  1201  RKHKAVVEKI GEENNKVVEE LIEENNDMKN KLEELQTLCK TPPRSLSAGA IENACLPCSG
  1261  GALEELRGQY IKAVKKIKCD MLRYIQESKE RAAEMVKAEV LRERQETARK MRKYYLICLQ
  1321  QILQDDGKEG AEKKIMNAAS KLATMAKLLE TPISSKSQSK TTQSALPLTS EMLIAVKKSK
  1381  RNDVNQKIPC CIESKSNSVN TITRTLCEQA PKRRAACNLQ RLLENSEHQS IKHVGSKETH
  1441  LEFQFGDGSC KHLNSLPRNV SPEFVPCEGE GGFGLHKKKD LLSDNGSESL PHSAAYPFLG
  1501  TLGNKPSPRC TPGPSESGCM HITFRDSNER LGLKVYKCNP LMESENAASE KSQGLDVQEP
  1561  PVKDGGDLSD CLGWPSSSAT LSFDSREASF VHGRPQGTLE IPSESVKSKQ FSPSGYLSDT
  1621  EESNMICQTM KCQRYQTPYL SEETTYLEPG KISVNCGHPS RHKADRLKSD FKKLSSTLPS
  1681  SVCQQPSRKL IVPLSSQQDS GFDSPFVNLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP152 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
testis: 9.2 nTPM
thymus: 5.2 nTPM
placenta: 4.4 nTPM
lymph node: 4 nTPM
tonsil: 3.5 nTPM

Single-cell type

early spermatids: 312 nCPM
erythrocyte progenitors: 132 nCPM
monocyte progenitors: 116 nCPM
renal collecting duct intercalated cells: 105 nCPM
late primary spermatocytes: 92 nCPM
neutrophil progenitors: 74 nCPM

Immune cell

basophil: 2.1 nTPM
eosinophil: 1.9 nTPM
neutrophil: 1.9 nTPM
naive B-cell: 1.7 nTPM
non-classical monocyte: 1.5 nTPM
plasmacytoid DC: 1.5 nTPM

Brain region

choroid plexus: 7.9 nTPM
cerebellum: 6.4 nTPM
thalamus: 6.3 nTPM
cerebral cortex: 6.2 nTPM
white matter: 5.9 nTPM
pons: 5.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEP152.

Disease | AllUniProt

Conditions CEP152 is implicated in, by any mechanism.

Microcephaly 9, primary, autosomal recessive (MCPH9) MIM:614852
Seckel syndrome 5 (SCKL5) MIM:613823

Disease | GeneticClinVar

143 pathogenic / likely-pathogenic of 1,256 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly 9, primary, autosomal recessive
Seckel syndrome 5
CEP152-related disorder
Inborn genetic diseases
Seckel syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centrosomal Protein 152/SHC-Transforming Protein
CEP152, CEP63 binding coiled coil
CEP152, PLK4 binding region
CEP152, PLK4 binding region
CEP152, CEP63 binding coiled coil

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP152 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP152 as an antibody target. Whether an autoantibody or antibody against CEP152 could matter depends on whether native CEP152 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP152 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP152 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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