Seroatlas · Human Serome Atlas

SDCCAG8

Serologically defined colon cancer antigen 8

Also known as: BBS16, CCCAP, NPHP10, NY-CO-8, SDCG8_HUMAN, SLSN7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86SQ7
Gene
SDCCAG8
Ensembl
ENSG00000054282
Chromosome
1
Canonical length
713 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Primary cilium,Centrosome,Basal body
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

713 residues, UniProt reviewed canonical sequence.

>Q86SQ7|SDCCAG8
     1  MAKSPENSTL EEILGQYQRS LREHASRSIH QLTCALKEGD VTIGEDAPNL SFSTSVGNED
    61  ARTAWPELQQ SHAVNQLKDL LRQQADKESE VSPSRRRKMS PLRSLEHEET NMPTMHDLVH
   121  TINDQSQYIH HLEAEVKFCK EELSGMKNKI QVVVLENEGL QQQLKSQRQE ETLREQTLLD
   181  ASGNMHNSWI TTGEDSGVGE TSKRPFSHDN ADFGKAASAG EQLELEKLKL TYEEKCEIEE
   241  SQLKFLRNDL AEYQRTCEDL KEQLKHKEFL LAANTCNRVG GLCLKCAQHE AVLSQTHTNV
   301  HMQTIERLVK ERDDLMSALV SVRSSLADTQ QREASAYEQV KQVLQISEEA NFEKTKALIQ
   361  CDQLRKELER QAERLEKELA SQQEKRAIEK DMMKKEITKE REYMGSKMLI LSQNIAQLEA
   421  QVEKVTKEKI SAINQLEEIQ SQLASREMDV TKVCGEMRYQ LNKTNMEKDE AEKEHREFRA
   481  KTNRDLEIKD QEIEKLRIEL DESKQHLEQE QQKAALAREE CLRLTELLGE SEHQLHLTRQ
   541  EKDSIQQSFS KEAKAQALQA QQREQELTQK IQQMEAQHDK TENEQYLLLT SQNTFLTKLK
   601  EECCTLAKKL EQISQKTRSE IAQLSQEKRY TYDKLGKLQR RNEELEEQCV QHGRVHETMK
   661  QRLRQLDKHS QATAQQLVQL LSKQNQLLLE RQSLSEEVDR LRTQLPSMPQ SDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDCCAG8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 16 nTPM
  • pancreas: 14 nTPM
  • spinal cord: 14 nTPM
  • midbrain: 12 nTPM
  • amygdala: 12 nTPM
  • hippocampal formation: 12 nTPM

Single-cell type

  • microglia: 729 nCPM
  • oligodendrocytes: 400 nCPM
  • choroid plexus epithelial cells: 363 nCPM
  • ependymal cells: 300 nCPM
  • astrocytes: 262 nCPM
  • distal convoluted tubule cells: 260 nCPM

Immune cell

  • NK-cell: 9 nTPM
  • intermediate monocyte: 8 nTPM
  • basophil: 7.8 nTPM
  • classical monocyte: 7.8 nTPM
  • myeloid DC: 7.1 nTPM
  • naive B-cell: 6.9 nTPM

Brain region

  • white matter: 14 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 13 nTPM
  • midbrain: 12 nTPM
  • hippocampal formation: 11 nTPM
  • pons: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SDCCAG8.

Disease | AllUniProt

Conditions SDCCAG8 is implicated in, by any mechanism.

Disease | GeneticClinVar

92 pathogenic / likely-pathogenic of 807 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Serologically defined colon cancer antigen 8
  • Centrosomal colon cancer autoantigen protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDCCAG8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDCCAG8 as an antibody target. Whether an autoantibody or antibody against SDCCAG8 could matter depends on whether native SDCCAG8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDCCAG8 is annotated at the cell surface, where native SDCCAG8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SDCCAG8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SDCCAG8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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