Seroatlas · Human Serome Atlas

CENPP

Centromere protein P

Also known as: CENP-P, CENPP_HUMAN, RP11-19J3.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IPU0
Gene
CENPP
Ensembl
ENSG00000188312
Chromosome
9
Canonical length
288 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q6IPU0|CENPP
     1  MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW KSSKDLKNQL
    61  GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK VLQRHRLSGN CHMVTFQLEF
   121  QILEIQNKER LSSAVTDLNI IMEPTECSEL SEFVSRAEER KDLFMFFRSL HFFVEWFEYR
   181  KRTFKHLKEK YPDAVYLSEG PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT
   241  KVPQRALELD KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • skin: 20 nTPM
  • bone marrow: 12 nTPM
  • skeletal muscle: 8.3 nTPM
  • thymus: 6.6 nTPM
  • tonsil: 6 nTPM
  • lymph node: 5.2 nTPM

Single-cell type

  • erythrocyte progenitors: 623 nCPM
  • monocyte progenitors: 527 nCPM
  • neutrophil progenitors: 405 nCPM
  • early primary spermatocytes: 400 nCPM
  • megakaryocyte progenitors: 354 nCPM
  • adipocytes: 296 nCPM

Immune cell

  • intermediate monocyte: 6.4 nTPM
  • MAIT T-cell: 4.7 nTPM
  • memory B-cell: 4.6 nTPM
  • naive B-cell: 3.7 nTPM
  • NK-cell: 3.5 nTPM
  • T-reg: 3.5 nTPM

Brain region

  • cerebellum: 16 nTPM
  • basal ganglia: 8.3 nTPM
  • cerebral cortex: 8.1 nTPM
  • hippocampal formation: 8.1 nTPM
  • pons: 8.1 nTPM
  • thalamus: 8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CENPP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Low-frequency hearing loss
  • Low-frequency sensorineural hearing impairment

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.05
gnomAD missense Z
0.32
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centromere protein P
  • CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPP as an antibody target. Whether an autoantibody or antibody against CENPP could matter depends on whether native CENPP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CENPP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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