Seroatlas · Human Serome Atlas

CENPN

Centromere protein N

Also known as: BM039, C16orf60, CENPN_HUMAN, FLJ13607, FLJ22660

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H22
Gene: CENPN
Ensembl: ENSG00000166451
Chromosome: 16
Canonical length: 339 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q96H22|CENPN
     1  MDETVAEFIK RTILKIPMNE LTTILKAWDF LSENQLQTVN FRQRKESVVQ HLIHLCEEKR
    61  ASISDAALLD IIYMQFHQHQ KVWEVFQMSK GPGEDVDLFD MKQFKNSFKK ILQRALKNVT
   121  VSFRETEENA VWIRIAWGTQ YTKPNQYKPT YVVYYSQTPY AFTSSSMLRR NTPLLGQALT
   181  IASKHHQIVK MDLRSRYLDS LKAIVFKQYN QTFETHNSTT PLQERSLGLD INMDSRIIHE
   241  NIVEKERVQR ITQETFGDYP QPQLEFAQYK LETKFKSGLN GSILAEREEP LRCLIKFSSP
   301  HLLEALKSLA PAGIADAPLS PLLTCIPNKR MNYFKIRDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 35 nTPM
prostate: 22 nTPM
thymus: 17 nTPM
tonsil: 11 nTPM
testis: 11 nTPM
lymph node: 10 nTPM

Single-cell type

extravillous trophoblasts: 111 nCPM
gastric progenitor cells: 91 nCPM
migrating cytotrophoblasts: 90 nCPM
esophageal basal cells: 79 nCPM
prostatic glandular cells: 78 nCPM
early primary spermatocytes: 67 nCPM

Immune cell

T-reg: 7.9 nTPM
myeloid DC: 6.6 nTPM
naive B-cell: 6 nTPM
NK-cell: 3.6 nTPM
non-classical monocyte: 3.1 nTPM
intermediate monocyte: 2.8 nTPM

Brain region

white matter: 18 nTPM
midbrain: 15 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: -1.37
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centromere protein Chl4/mis15/CENP-N
Centromere-associated NAC/CAD complex protein
Kinetochore protein CHL4 like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPN as an antibody target. Whether an autoantibody or antibody against CENPN could matter depends on whether native CENPN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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