Seroatlas · Human Serome Atlas

C1QL4

Complement C1q-like protein 4

Also known as: C1QL4_HUMAN, C1QTNF11, CTRP11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Z23
Gene: C1QL4
Ensembl: ENSG00000186897
Chromosome: 12
Canonical length: 238 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles,Cytosol
Secretome location: Secreted in brain
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q86Z23|C1QL4
     1  MVLLLLVAIP LLVHSSRGPA HYEMLGRCRM VCDPHGPRGP GPDGAPASVP PFPPGAKGEV
    61  GRRGKAGLRG PPGPPGPRGP PGEPGRPGPP GPPGPGPGGV APAAGYVPRI AFYAGLRRPH
   121  EGYEVLRFDD VVTNVGNAYE AASGKFTCPM PGVYFFAYHV LMRGGDGTSM WADLMKNGQV
   181  RASAIAQDAD QNYDYASNSV ILHLDVGDEV FIKLDGGKVH GGNTNKYSTF SGFIIYPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

testis: 3.9 nTPM
amygdala: 1 nTPM
hypothalamus: 1 nTPM
kidney: 1 nTPM
vagina: 1 nTPM
thyroid gland: 0.9 nTPM

Single-cell type

late spermatids: 177 nCPM
early spermatids: 43 nCPM
late primary spermatocytes: 13 nCPM
early primary spermatocytes: 9.7 nCPM
retinal horizontal cells: 8 nCPM
melanocytes: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 16 nTPM
midbrain: 3.4 nTPM
hypothalamus: 3.2 nTPM
cerebral cortex: 3.1 nTPM
medulla oblongata: 1.8 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.42
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QL4 as an antibody target. Whether an autoantibody or antibody against C1QL4 could matter depends on whether native C1QL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QL4 is annotated as secreted, so native C1QL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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