Seroatlas · Human Serome Atlas

C1QL3

Complement C1q-like protein 3

Also known as: C1ql, C1QL3_HUMAN, C1QTNF13, CTRP13, K100

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VWW1
Gene
C1QL3
Ensembl
ENSG00000165985
Chromosome
10
Canonical length
255 aa
Protein class
Predicted secreted proteins
Subcellular location
Vesicles,Cytosol
Secretome location
Secreted in brain
Quaternary structure
Homooligomer

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane and postsynaptic density assembly. Predicted to act upstream of or within regulation of synapse organization. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q5VWW1|C1QL3
     1  MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG LMQSLPTFIQ
    61  GPKGEAGRPG KAGPRGPPGE PGPPGPMGPP GEKGEPGRQG LPGPPGAPGL NAAGAISAAT
   121  YSTVPKIAFY AGLKRQHEGY EVLKFDDVVT NLGNHYDPTT GKFTCSIPGI YFFTYHVLMR
   181  GGDGTSMWAD LCKNNQVRAS AIAQDADQNY DYASNSVVLH LEPGDEVYIK LDGGKAHGGN
   241  NNKYSTFSGF IIYAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 26 nTPM
  • retina: 6.9 nTPM
  • cerebellum: 4.8 nTPM
  • hippocampal formation: 4.2 nTPM
  • amygdala: 3.3 nTPM
  • hypothalamus: 2.3 nTPM

Single-cell type

  • rod photoreceptor cells: 17 nCPM
  • cardiomyocytes: 16 nCPM
  • brain excitatory neurons: 13 nCPM
  • epicardial cells: 9.1 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • myonuclei: 7.5 nCPM

Immune cell

  • naive CD8 T-cell: 0.5 nTPM
  • gdT-cell: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM
  • T-reg: 0.4 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM

Brain region

  • hippocampal formation: 145 nTPM
  • cerebral cortex: 123 nTPM
  • basal ganglia: 121 nTPM
  • amygdala: 102 nTPM
  • white matter: 53 nTPM
  • thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.52
gnomAD missense Z
2.12
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QL3 as an antibody target. Whether an autoantibody or antibody against C1QL3 could matter depends on whether native C1QL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QL3 is annotated as secreted, so native C1QL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1QL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...