Seroatlas · Human Serome Atlas

C1QL1

C1q-related factor

Also known as: C1QRF, C1QRF_HUMAN, C1QTNF14, CRF, CTRP14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75973
Gene
C1QL1
Ensembl
ENSG00000131094
Chromosome
17
Canonical length
258 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Vesicles,Cytosol
Secretome location
Secreted in brain

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in locomotory behavior. Predicted to act upstream of or within maintenance of synapse structure; motor learning; and neuron remodeling. Predicted to be located in several cellular components, including climbing fiber; extracellular region; and presynapse. Predicted to be part of collagen trimer. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse and synaptic cleft. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>O75973|C1QL1
     1  MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD ALSEQSGAPP
    61  PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG EPGKPGPPGL PGAGGSGAIS
   121  TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV
   181  LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH
   241  GGNSNKYSTF SGFIIYSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 42 nTPM
  • hypothalamus: 34 nTPM
  • cerebral cortex: 34 nTPM
  • hippocampal formation: 31 nTPM
  • midbrain: 31 nTPM
  • spinal cord: 27 nTPM

Single-cell type

  • retinal horizontal cells: 435 nCPM
  • oligodendrocyte progenitor cells: 186 nCPM
  • retinal amacrine cells: 111 nCPM
  • pancreatic islet cells: 82 nCPM
  • podocytes: 74 nCPM
  • mesothelial cells: 38 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 286 nTPM
  • cerebral cortex: 95 nTPM
  • midbrain: 91 nTPM
  • spinal cord: 73 nTPM
  • cerebellum: 59 nTPM
  • white matter: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
1.25
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QL1 as an antibody target. Whether an autoantibody or antibody against C1QL1 could matter depends on whether native C1QL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QL1 is annotated as secreted, so native C1QL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1QL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...