Seroatlas · Human Serome Atlas

ELMO3

Engulfment and cell motility protein 3

Also known as: CED-12, CED12, ELMO-3, ELMO3_HUMAN, FLJ13824

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BJ8
Gene: ELMO3
Ensembl: ENSG00000102890
Chromosome: 16
Canonical length: 720 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

720 residues, UniProt reviewed canonical sequence.

>Q96BJ8|ELMO3
     1  MAPPRNVVKI AIKMRDAIPQ LIQLDQAKPL AAVLKEVCDA WSLTHSERYA LQFADGHRRY
    61  ITENNRAEIK NGSILCLSTA PDLEAEQLLG GLQSNSPEGR REALRRLVPL ASDMIFAREV
   121  ISRNGLQILG TIIEDGDDLG EVLALSLRAF SELMEHGVVS WETLSIPFVR KVVCYVNMNL
   181  MDASVPPLAL GLLESVTLSS PALGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ
   241  GASPVERKHM LDYLWQRNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALML GLLEPRMRTP
   301  LDPYSQEQRE QLQVLRQAAF EVEGESSGAG LSADRRRSLC AREFRKLGFS NSNPAQDLER
   361  VPPGLLALDN MLYFSRNAPS AYSRFVLENS SREDKHECPF ARGSIQLTVL LCELLRVGEP
   421  CSETAQDFSP MFFGQDQSFH ELFCVGIQLL NKTWKEMRAT QEDFDKVMQV VREQLARTLA
   481  LKPTSLELFR TKVNALTYGE VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL
   541  LRLCEGTLFR KISSRRRQDK LWFCCLSPNH KLLQYGDMEE GASPPTLESL PEQLPVADMR
   601  ALLTGKDCPH VREKGSGKQN KDLYELAFSI SYDRGEEEAY LNFIAPSKRE FYLWTDGLSA
   661  LLGSPMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPERPP PVPPPPTNFN FCYDCSIAEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELMO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

pancreas: 40 nTPM
skin: 32 nTPM
duodenum: 31 nTPM
pituitary gland: 29 nTPM
kidney: 29 nTPM
stomach: 25 nTPM

Single-cell type

breast lactating cells: 97 nCPM
enterocytes: 88 nCPM
late spermatids: 67 nCPM
colonocytes: 64 nCPM
enteric transient amplifying cells: 47 nCPM
foveolar cells: 46 nCPM

Immune cell

neutrophil: 0.3 nTPM
memory B-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebral cortex: 11 nTPM
pons: 11 nTPM
cerebellum: 9.6 nTPM
hypothalamus: 8.3 nTPM
medulla oblongata: 8.2 nTPM
amygdala: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH3 domain binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELMO3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ADGRB3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELMO3 as an antibody target. Whether an autoantibody or antibody against ELMO3 could matter depends on whether native ELMO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELMO3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELMO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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