Seroatlas · Human Serome Atlas

C1QL2

Complement C1q-like protein 2

Also known as: C1QL2_HUMAN, C1QTNF10, CTRP10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z5L3
Gene
C1QL2
Ensembl
ENSG00000144119
Chromosome
2
Canonical length
287 aa
Protein class
Predicted secreted proteins, Transporters
Subcellular location
Vesicles,Cytosol
Secretome location
Secreted in brain
Quaternary structure
Homotrimer

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic density assembly; and regulation of synapse maturation. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q7Z5L3|C1QL2
     1  MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ PPGPSTAALE
    61  VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG PRGPPGEKGD SGRPGLPGLQ
   121  LTAGTASGVG VVGGGAGVGG DSEGEVTSAL SATFSGPKIA FYVGLKSPHE GYEVLKFDDV
   181  VTNLGNHYDP TTGKFSCQVR GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ
   241  NYDYASNSVV LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 26 nTPM
  • amygdala: 24 nTPM
  • cerebral cortex: 18 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 11 nTPM
  • midbrain: 7.6 nTPM

Single-cell type

  • retinal amacrine cells: 151 nCPM
  • oligodendrocyte progenitor cells: 52 nCPM
  • astrocytes: 6.6 nCPM
  • brain excitatory neurons: 4.7 nCPM
  • other brain neurons: 4.6 nCPM
  • breast secretory cells: 3.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 49 nTPM
  • hypothalamus: 36 nTPM
  • amygdala: 31 nTPM
  • cerebral cortex: 29 nTPM
  • thalamus: 20 nTPM
  • basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0.04
gnomAD missense Z
1.65
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QL2 as an antibody target. Whether an autoantibody or antibody against C1QL2 could matter depends on whether native C1QL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QL2 is annotated as secreted, so native C1QL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1QL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...