RWD domain

Definition

This domain was identified in WD40 repeat proteins and Ring finger domain proteins PMID:11779830. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain PMID:11779830 after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices PMID:15273307.

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• DHX57
• EIF2AK4
• IMPACT
• RNF14
• RNF25
• RWDD1
• RWDD2A
• RWDD2B
• RWDD3
• RWDD4
• UBE2Q2