Seroatlas · Human Serome Atlas

RWDD2B

RWD domain-containing protein 2B

Also known as: C21orf6, GL011, RWD2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57060
Gene: RWDD2B
Ensembl: ENSG00000156253
Chromosome: 21
Canonical length: 319 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RWDD2B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>P57060|RWDD2B
     1  MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF PGENELIVND
    61  QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM FSLACILPFK YPAVLPEITV
   121  RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC ILNATEWVRE HASGYVSRDT SSSPTTGSTV
   181  QSVDLIFTRL WIYSHHIYNK CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW
   241  SRLRKLNWKR ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF
   301  LNTKGCGDVF QMFFGVEGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RWDD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 3.3 nTPM
tongue: 2.7 nTPM
heart muscle: 1.3 nTPM
skin: 1.2 nTPM
cerebral cortex: 1.1 nTPM
liver: 1.1 nTPM

Single-cell type

early primary spermatocytes: 40 nCPM
late primary spermatocytes: 39 nCPM
hepatocytes: 30 nCPM
parietal cells: 25 nCPM
megakaryocytes: 25 nCPM
myonuclei: 25 nCPM

Immune cell

basophil: 3.1 nTPM
neutrophil: 1.2 nTPM
memory B-cell: 0.8 nTPM
non-classical monocyte: 0.7 nTPM
gdT-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM

Brain region

cerebral cortex: 5.2 nTPM
white matter: 5.2 nTPM
cerebellum: 4.9 nTPM
pons: 4.8 nTPM
hippocampal formation: 4.6 nTPM
basal ganglia: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RWDD2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RWDD2B as an antibody target. Whether an autoantibody or antibody against RWDD2B could matter depends on whether native RWDD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RWDD2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RWDD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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