Seroatlas · Human Serome Atlas

UBE2Q2

Ubiquitin-conjugating enzyme E2 Q2

Also known as: DKFZp762C143, UB2Q2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVN8
Gene: UBE2Q2
Ensembl: ENSG00000140367
Chromosome: 15
Canonical length: 375 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q8WVN8|UBE2Q2
     1  MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PQQGSPHSLP PPLTLHCNIT
    61  ESYPSSSPIW FVDSEDPNLT SVLERLEDTK NNNLLRQQLK WLICELCSLY NLPKHLDVEM
   121  LDQPLPTGQN GTTEEVTSEE EEEEEEMAED IEDLDHYEMK EEEPISGKKS EDEGIEKENL
   181  AILEKIRKTQ RQDHLNGAVS GSVQASDRLM KELRDIYRSQ SYKTGIYSVE LINDSLYDWH
   241  VKLQKVDPDS PLHSDLQILK EKEGIEYILL NFSFKDNFPF DPPFVRVVLP VLSGGYVLGG
   301  GALCMELLTK QGWSSAYSIE SVIMQINATL VKGKARVQFG ANKNQYNLAR AQQSYNSIVQ
   361  IHEKNGWYTP PKEDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2Q2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 38 nTPM
retina: 36 nTPM
colon: 35 nTPM
spinal cord: 30 nTPM
thyroid gland: 30 nTPM
blood vessel: 29 nTPM

Single-cell type

cone photoreceptor cells: 356 nCPM
rod photoreceptor cells: 243 nCPM
extravillous trophoblasts: 229 nCPM
syncytiotrophoblasts: 165 nCPM
ocular epithelial cells: 155 nCPM
gonadotrophs: 128 nCPM

Immune cell

basophil: 31 nTPM
eosinophil: 21 nTPM
NK-cell: 15 nTPM
memory CD4 T-cell: 12 nTPM
MAIT T-cell: 11 nTPM
non-classical monocyte: 10 nTPM

Brain region

white matter: 32 nTPM
spinal cord: 30 nTPM
midbrain: 30 nTPM
pons: 29 nTPM
hypothalamus: 28 nTPM
medulla oblongata: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein K48-linked ubiquitination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2Q2 as an antibody target. Whether an autoantibody or antibody against UBE2Q2 could matter depends on whether native UBE2Q2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2Q2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2Q2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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