Seroatlas · Human Serome Atlas

RWDD4

RWD domain-containing protein 4

Also known as: FAM28A, MGC10198, RWDD4_HUMAN, RWDD4A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NW29
Gene: RWDD4
Ensembl: ENSG00000182552
Chromosome: 4
Canonical length: 188 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments

OverviewNCBI Gene

No narrative summary is available for RWDD4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q6NW29|RWDD4
     1  MSANEDQEME LEALRSIYEG DESFRELSPV SFQYRIGENG DPKAFLIEIS WTETYPQTPP
    61  ILSMNAFFNN TISSAVKQSI LAKLQEAVEA NLGTAMTYTL FEYAKDNKEQ FMENHNPINS
   121  ATSISNIISI ETPNTAPSSK KKDKKEQLSK AQKRKLADKT DHKGELPRGW NWVDVVKHLS
   181  KTGSKDDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RWDD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 49 nTPM
ovary: 43 nTPM
skeletal muscle: 42 nTPM
tongue: 30 nTPM
pancreas: 25 nTPM
kidney: 22 nTPM

Single-cell type

epididymal clear cells: 96 nCPM
thymic myoid cells: 84 nCPM
gonadotrophs: 81 nCPM
epididymal efferent duct ciliated cells: 81 nCPM
ovarian stromal cells: 72 nCPM
differentiating spermatogonia: 65 nCPM

Immune cell

eosinophil: 6.8 nTPM
NK-cell: 6.5 nTPM
T-reg: 5.7 nTPM
non-classical monocyte: 5.5 nTPM
plasmacytoid DC: 4.7 nTPM
intermediate monocyte: 4.5 nTPM

Brain region

choroid plexus: 22 nTPM
hypothalamus: 16 nTPM
cerebellum: 14 nTPM
midbrain: 13 nTPM
medulla oblongata: 12 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.02
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Acetylation

InteractionsUniProt · HPA

Protein binding partners of RWDD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF330

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RWDD4 as an antibody target. Whether an autoantibody or antibody against RWDD4 could matter depends on whether native RWDD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RWDD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RWDD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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