RWDD2A
RWD domain-containing protein 2A
Also known as: dJ747H23.2, MGC13523, RWD2A_HUMAN, RWDD2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UIY3
- Gene
- RWDD2A
- Ensembl
- ENSG00000013392
- Chromosome
- 6
- Canonical length
- 292 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
No narrative summary is available for RWDD2A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>Q9UIY3|RWDD2A
1 MSASVKESLQ LQLLEMEMLF SMFPNQGEVK LEDVNALTNI KRYLEGTREA LPPKIEFVIT
61 LQIEEPKVKI DLQVTMPHSY PYVALQLFGR SSELDRHQQL LLNKGLTSYI GTFDPGELCV
121 CAAIQWLQDN SASYFLNRKL VYEPSTQAKP VKNTFLRMWI YSHHIYQQDL RKKILDVGKR
181 LDVTGFCMTG KPGIICVEGF KEHCEEFWHT IRYPNWKHIS CKHAESVETE GNGEDLRLFH
241 SFEELLLEAH GDYGLRNDYH MNLGQFLEFL KKHKSEHVFQ ILFGIESKSS DSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RWDD2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- prostate: 11 nTPM
- pancreas: 9.1 nTPM
- epididymis: 8.8 nTPM
- testis: 8.3 nTPM
- cerebral cortex: 7.1 nTPM
- cerebellum: 6.8 nTPM
Single-cell type
- late primary spermatocytes: 129 nCPM
- prostatic glandular cells: 44 nCPM
- early spermatids: 33 nCPM
- retinal pigment epithelial cells: 26 nCPM
- epididymal principal cells: 25 nCPM
- early primary spermatocytes: 20 nCPM
Immune cell
- plasmacytoid DC: 3.5 nTPM
- non-classical monocyte: 2.3 nTPM
- naive CD4 T-cell: 2.2 nTPM
- T-reg: 2.2 nTPM
- naive CD8 T-cell: 2.1 nTPM
- memory B-cell: 1.9 nTPM
Brain region
- hypothalamus: 13 nTPM
- basal ganglia: 10 nTPM
- cerebral cortex: 9.7 nTPM
- choroid plexus: 8.5 nTPM
- cerebellum: 8.2 nTPM
- midbrain: 8.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.62
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.07
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RWDD2A as an antibody target. Whether an autoantibody or antibody against RWDD2A could matter depends on whether native RWDD2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RWDD2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RWDD2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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