Shisa, N-terminal domain
IPR053891
Definition
Shisa is a transmembrane, transcription factor-type protein that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface. Vertebrate homologues play roles in development, cancer and apoptosis [[cite:PMID:15680328], [cite:PMID:18033675], [cite:PMID:22120523]]. This entry represents a domain found in the N-terminal region, which contains six conserved cysteines. Members of this family are found mainly in vertebrates but also in other animal species.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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