Seroatlas · Human Serome Atlas

SHISA6

Protein shisa-6

Also known as: FLJ45455, SHSA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZSJ9
Gene
SHISA6
Ensembl
ENSG00000188803
Chromosome
17
Canonical length
500 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; modulation of chemical synaptic transmission; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine membrane; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q6ZSJ9|SHISA6
     1  MALRRLLLLL LLSLESLDLL PSVHGARGRA ANRTLSAGGA AVGGRRAGGA LARGGRELNG
    61  TARAPGIPEA GSRRGQPAAA VAAAASAAVT YETCWGYYDV SGQYDKEFEC NNSESGYLYC
   121  CGTCYYRFCC KKRHEKLDQR QCTNYQSPVW VQTPSTKVVS PGPENKYDPE KDKTNFTVYI
   181  TCGVIAFVIV AGVFAKVSYD KAHRPPREMN IHRALADILR QQGPIPIAHC ERETISAIDT
   241  SPKENTPVRS SSKNHYTPVR TAKQTPEKPR MNNILTSATE PYDLSFSRSF QNLAHLPPSY
   301  ESAVKTNPSK YSSLKRLTDK EADEYYMRRR HLPDLAARGT LPLNVIQMSQ QKPLPRERPR
   361  RPIRAMSQDR VLSPDRGLPD EFSMPYDRIL SDEQLLSTER LHSQDPLLSP ERTAFPEQSL
   421  SRAISHTDVF VSTPVLDRYR MSKMHSHPSA SNNSYATLGQ SQTAAKRHAF ASRRHNTVEQ
   481  LHYIPGHHTC YTASKTEVTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 17 nTPM
  • cervix: 16 nTPM
  • hippocampal formation: 16 nTPM
  • hypothalamus: 13 nTPM
  • cerebellum: 12 nTPM
  • spinal cord: 9.7 nTPM

Single-cell type

  • adipocytes: 378 nCPM
  • bergmann glia: 268 nCPM
  • endometrial stromal cells: 225 nCPM
  • peritubular myoid cells: 220 nCPM
  • epicardial cells: 218 nCPM
  • brain excitatory neurons: 182 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 102 nTPM
  • spinal cord: 100 nTPM
  • medulla oblongata: 97 nTPM
  • thalamus: 78 nTPM
  • white matter: 60 nTPM
  • midbrain: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.85
gnomAD missense Z
2.15
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISA6 as an antibody target. Whether an autoantibody or antibody against SHISA6 could matter depends on whether native SHISA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISA6 is annotated at the cell surface, where native SHISA6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SHISA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHISA6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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