Seroatlas · Human Serome Atlas

SHISA2

Protein shisa-2 homolog

Also known as: bA398O19.2, C13orf13, hShisa, PRO28631, SHSA2_HUMAN, TMEM46, WGAR9166

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWI4
Gene: SHISA2
Ensembl: ENSG00000180730
Chromosome: 13
Canonical length: 295 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q6UWI4|SHISA2
     1  MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI GFQCPERFDG
    61  GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG RADKDGPDGS AVPIYVPFLI
   121  VGSVFVAFII LGSLVAACCC RCLRPKQDPQ QSRAPGGNRL METIPMIPSA STSRGSSSRQ
   181  SSTAASSSSS ANSGARAPPT RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG
   241  QYLHPPYVGY TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 20 nTPM
skeletal muscle: 13 nTPM
breast: 12 nTPM
epididymis: 7.4 nTPM
lung: 4.1 nTPM
kidney: 3.5 nTPM

Single-cell type

respiratory ionocytes: 58 nCPM
medullary thymic epithelial cells: 43 nCPM
breast hormone-responsive cells: 42 nCPM
epididymal clear cells: 35 nCPM
conjunctival goblet cells: 31 nCPM
respiratory secretory cells: 26 nCPM

Immune cell

naive CD8 T-cell: 1.6 nTPM
naive CD4 T-cell: 1 nTPM
basophil: 0.8 nTPM
eosinophil: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
neutrophil: 0.4 nTPM

Brain region

white matter: 12 nTPM
basal ganglia: 5.4 nTPM
spinal cord: 5.2 nTPM
hippocampal formation: 5 nTPM
cerebral cortex: 4.9 nTPM
medulla oblongata: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.07
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISA2 as an antibody target. Whether an autoantibody or antibody against SHISA2 could matter depends on whether native SHISA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHISA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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