Seroatlas · Human Serome Atlas

SHISA4

Protein shisa-4

Also known as: C1orf40, hShisa4, SHSA4_HUMAN, TMEM58

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DD7
Gene
SHISA4
Ensembl
ENSG00000198892
Chromosome
1
Canonical length
197 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q96DD7|SHISA4
     1  MPPAGLRRAA PLTAIALLVL GAPLVLAGED CLWYLDRNGS WHPGFNCEFF TFCCGTCYHR
    61  YCCRDLTLLI TERQQKHCLA FSPKTIAGIA SAVILFVAVV ATTICCFLCS CCYLYRRRQQ
   121  LQSPFEGQEI PMTGIPVQPV YPYPQDPKAG PAPPQPGFIY PPSGPAPQYP LYPAGPPVYN
   181  PAAPPPYMPP QPSYPGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
206 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 206 nTPM
  • tongue: 54 nTPM
  • amygdala: 51 nTPM
  • midbrain: 44 nTPM
  • basal ganglia: 43 nTPM
  • hippocampal formation: 40 nTPM

Single-cell type

  • decidual stromal cells: 53 nCPM
  • oligodendrocytes: 47 nCPM
  • extravillous trophoblasts: 38 nCPM
  • oligodendrocyte progenitor cells: 38 nCPM
  • bergmann glia: 36 nCPM
  • breast myoepithelial cells: 35 nCPM

Immune cell

  • eosinophil: 25 nTPM
  • non-classical monocyte: 10 nTPM
  • neutrophil: 9.1 nTPM
  • intermediate monocyte: 8.1 nTPM
  • classical monocyte: 1.7 nTPM
  • gdT-cell: 1.7 nTPM

Brain region

  • basal ganglia: 108 nTPM
  • thalamus: 102 nTPM
  • cerebral cortex: 96 nTPM
  • midbrain: 95 nTPM
  • amygdala: 94 nTPM
  • medulla oblongata: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.94
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISA4 as an antibody target. Whether an autoantibody or antibody against SHISA4 could matter depends on whether native SHISA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISA4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHISA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHISA4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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