Seroatlas · Human Serome Atlas

SHISA5

Protein shisa-5

Also known as: hShisa5, SCOTIN, SHSA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N114
Gene: SHISA5
Ensembl: ENSG00000164054
Chromosome: 3
Canonical length: 240 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q8N114|SHISA5
     1  MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG TCDDQYCCSD
    61  VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN DPMSGFGATL AVGLTIFVLS
   121  VVTIIICFTC SCCCLYKTCR RPRPVVTTTT STTVVHAPYP QPPSVPPSYP GPSYQGYHTM
   181  PPQPGMPAAP YPMQYPPPYP AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 178 nTPM
esophagus: 136 nTPM
placenta: 130 nTPM
blood vessel: 114 nTPM
urinary bladder: 112 nTPM
spleen: 106 nTPM

Single-cell type

neutrophils: 365 nCPM
migrating cytotrophoblasts: 346 nCPM
cytotrophoblasts: 336 nCPM
extravillous trophoblasts: 266 nCPM
esophageal suprabasal cells: 179 nCPM
esophageal basal cells: 163 nCPM

Immune cell

neutrophil: 939 nTPM
total PBMC: 500 nTPM
T-reg: 364 nTPM
gdT-cell: 321 nTPM
classical monocyte: 309 nTPM
non-classical monocyte: 307 nTPM

Brain region

choroid plexus: 192 nTPM
hypothalamus: 118 nTPM
medulla oblongata: 93 nTPM
midbrain: 89 nTPM
amygdala: 87 nTPM
thalamus: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHISA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PDCD6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISA5 as an antibody target. Whether an autoantibody or antibody against SHISA5 could matter depends on whether native SHISA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHISA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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