Seroatlas · Human Serome Atlas

SHISAL2B

Protein shisa-like-2B

Also known as: FAM159B, SHL2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NKW6
Gene
SHISAL2B
Ensembl
ENSG00000145642
Chromosome
5
Canonical length
160 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>A6NKW6|SHISAL2B
     1  MSEASRLCSG YYSLNQSFVE PFQCPRRGEG AALQYCCGFA DLKYCCSEPG SYFPYKHSYM
    61  WSLSIGALIG LGIAALVLLA FVISVCVLCY LFLYTKPQRL DTGLKLQHLE ASSTQEGKSN
   121  GKTKALNSNA ASNATNETYY EADDIIQEKT MDATQIHIAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISAL2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
4.6 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 4.6 nTPM
  • hypothalamus: 3.3 nTPM
  • stomach: 2.7 nTPM
  • basal ganglia: 0.6 nTPM
  • duodenum: 0.3 nTPM
  • hippocampal formation: 0.2 nTPM

Single-cell type

  • pancreatic islet cells: 99 nCPM
  • breast lactating cells: 22 nCPM
  • neuroendocrine cells: 12 nCPM
  • other brain neurons: 9.8 nCPM
  • undifferentiated spermatogonia: 6.2 nCPM
  • epicardial cells: 4.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 6.5 nTPM
  • medulla oblongata: 3.1 nTPM
  • cerebral cortex: 1.8 nTPM
  • basal ganglia: 1.2 nTPM
  • pons: 1.1 nTPM
  • amygdala: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
DepMap mean gene effect
0.05
DepMap dependency class
none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISAL2B as an antibody target. Whether an autoantibody or antibody against SHISAL2B could matter depends on whether native SHISAL2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISAL2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHISAL2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHISAL2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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