Seroatlas · Human Serome Atlas

SHISA8

Protein shisa-8

Also known as: C22orf17, Orf26, SHSA8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B8ZZ34
Gene: SHISA8
Ensembl: ENSG00000234965
Chromosome: 22
Canonical length: 397 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in regulation of short-term neuronal synaptic plasticity. Predicted to be located in membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine membrane; postsynaptic density; and postsynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>B8ZZ34|SHISA8
     1  MARAGARGLL GGRRPPGLRL ALALRLALLL ARPPSGRAGA PEAQGPAAPG TTAPEGGDRC
    61  RGYYDVMGQW DPPFNCSSGA YSFCCGTCGY RFCCHDGPRR LDQSRCSNYD TPAWVQTGRP
   121  PARARDTAAP RDPGRERSHT AVYAVCGVAA LLVLAGIGAR LGLERAHSPR ARRTVTRALT
   181  ELLKQPGPQE PLPPTLGPPL GGCVQVQMGD GLPRGSPHNS ADKKRLNNAP RGSAAPGPPR
   241  GPRLQGGGSL TLQPDYAKYA TFKAAALKAA EAAPRDFCQR FPALEPSPRQ PPARAPRPSP
   301  DLPAPLDACP WAPPVYAPPA APGPYAAWTS SRPARPAPLS HPTARAFQVP RRPGHAARRQ
   361  FSVKMPETFN PQLPGLYGSA GRGSRYLRTN SKTEVTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 57 nTPM
adrenal gland: 12 nTPM
cerebral cortex: 2.3 nTPM
spleen: 2.1 nTPM
spinal cord: 1.4 nTPM
pituitary gland: 1.3 nTPM

Single-cell type

breast lactating cells: 277 nCPM
retinal horizontal cells: 273 nCPM
oocytes: 272 nCPM
retinal amacrine cells: 55 nCPM
respiratory deuterosomal cells: 47 nCPM
brain excitatory neurons: 44 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 103 nTPM
spinal cord: 13 nTPM
thalamus: 13 nTPM
pons: 11 nTPM
cerebral cortex: 9.5 nTPM
midbrain: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.38
gnomAD missense Z: 0.56

OntologyGO

Biological processes

regulation of short-term neuronal synaptic plasticity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHISA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GRIA2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISA8 as an antibody target. Whether an autoantibody or antibody against SHISA8 could matter depends on whether native SHISA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISA8 is annotated at the cell surface, where native SHISA8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SHISA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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